Association between rs362746 polymorphism of RELN and Schizophrenia in Iranian Patients
Shima
Alimohammadi
Department of microbiology, karaj branch, Islamic Azad University, karaj, Iran
author
Fateme
Frootan
Maya Milk, Inc, Delaware, USA
author
text
article
2021
eng
Genetic studies, there is a potential association of RELN with some psychologicaldisorders such as Autism Spectrum Disorders (ASD) schizophrenia (SCZ). The RELNgene is located on chromosome 7q22.1 and encodes a large secretory protein of theextracellular matrix (Reelin). In the present case-control study, we intended to investigatethe relationship between the rs362746 polymorphism of RELN and schizophrenia in agroup of schizophrenic and healthy subjects from northeastern Iran.30 unrelated schizophrenic patients and 30 matched control subjects were recruited The samplesfrom the participants underwent PCR and sequencing for RELN genotype identification.he genotype distribution for both study and control groups were not in Hardy–Weinberg equilibrium(P>0.05).However, it was found that the prevalence ofrs362746 polymorphism was significantly different between the groups. the present study supported the evidence that rs362746 polymorphism of RELN was agenetic factor for schizophrenia susceptibility. However, there is a need for replicationstudies on different populations and further investigations on the sex-specific associationof this gene with schizophrenia.
Personalized Medicine Journal
AmitisGen TECH Dev Group
2476-5538
6
v.
21
no.
2021
1
3
https://www.pmjournal.ir/article_244727_d7646133fe618ba512c39af38308829d.pdf
dx.doi.org/10.22034/pmj.2021.244727
A relationship between two polymorphisms (rs2660 and rs1800450) and coronavirus (COVID-19) in Iranian population
Zahra
Sadeghi
Department of genetic, Tehran-North branch, Islamic azad university, Tehran,
Iran
author
Hossein
Pakzad
Department of biology, Tehran-east branch, Islamic azad university, Tehran,
Iran
author
Massoud
Houshmand
Department of Medical Genetics, National Institute for Genetic Engineering
and Biotechnology (NIGEB), Tehran, Iran
author
text
article
2021
eng
Warning of the World Health Organization (WHO) indicates that novel coronavirus (COVID-19) is pandemic and causes global concern. COVID-19 has acute respiratory symptoms which leads to die in many cases through the world. We have found seven variants in 300 patients based on Next Generation Sequencing (NGS) which are related to infectious disease. According to the databases, we confirmed that rs2660 and rs1800450 have association with COVID-19 in the Iranian population.
Personalized Medicine Journal
AmitisGen TECH Dev Group
2476-5538
6
v.
21
no.
2021
4
6
https://www.pmjournal.ir/article_244728_9fa0045b49906ec61c85af426dad2633.pdf
dx.doi.org/10.22034/pmj.2021.244728
Investigating the causes of antibiotic resistance in bacteria
AmirHossein
Akbari Aghababa
Department of Micrbiology, Faculty of biology, Islamic Azad University, North Branch,Tehran, Iran
author
Mona
Nadi
Department of Cell and Molecular Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
author
text
article
2021
eng
The discovery and production of (synthetic) antibiotics in the first half of the previous century has been one of medicine’s greatest achievements. The use of antimicrobial agents has reduced morbidity and mortality of humans and contributed substantially to human’s increased life span. The issue of antibiotic resistance has received considerable attention due to the problem of the emergence and rapid expansion of antibiotic-resistant pathogenic bacteria. Antibiotic resistance exhibited by bacteria can be intrinsic, acquired, or adaptive. Therefore, efforts to develop antibiotics and study mechanisms of resistance should be continuous, resilient and steady. In the following sections, we will focus on the molecular and biochemical mechanisms of bacterial resistance, illustrating specific situations that are often encountered in clinical practice.
Personalized Medicine Journal
AmitisGen TECH Dev Group
2476-5538
6
v.
21
no.
2021
7
11
https://www.pmjournal.ir/article_244729_f5c487cdfd822b31dbd1aad493e710e1.pdf
dx.doi.org/10.22034/pmj.2021.244729
Epithelial-mesenchymal transition in breast cancer
Naser
Gilani
Department of Biology, Gaziantep University, Gaziantep, Turkey
Farabi Molecular Laboratory, Irbil, Iraq
author
Mehmet
Ozaslan
Department of Biology, Gaziantep University, Gaziantep, Turkey
author
text
article
2021
eng
One of the key molecular mechanisms contributing to the metastatic progression is epithelial to mesenchymal transition (EMT), which drives invasion and migration of various cancer including breast cancer.During tumorigenesis, changes in EMT regulatory pathways lead to a loss of cellular adhesions, changes in the polarization of the cell and cytoskeleton, detachment, migration, intra-vasation, and survival in the vascular system; extravasation, and finally, metastasis.EMT is largely mediated by a core set of EMT-activating transcription factors. The master regulators of the EMT include many pathways, however the primary mediators of the EMT include signaling through TGF-, Notch and Wnt. The role of EMT in breast cancer has been demonstrated via numerous in vitro studies in normal and malignant mammary epithelial cells and via in vivo studies using mouse models of breast cancers. Studying the regulatory pathways of the EMT process can be used as a tool for cancer monitoring ,treatment and possible direct targets for new-combination anticancer personalized medicine.
Personalized Medicine Journal
AmitisGen TECH Dev Group
2476-5538
6
v.
21
no.
2021
12
16
https://www.pmjournal.ir/article_244731_e9071081de474040fced4dd0ee02639e.pdf
dx.doi.org/10.22034/pmj.2021.244731
Covid19 disease and the effect of genetic factors on its severity and weakness
Abbas
Ghasemzadeh
ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR,Tehran, Iran
author
Vahidreza
Esfahani
Department of Cellular and Molecular Tehran Medical Sciences Branch,lslamic Azad University, Tehran, Iran
author
text
article
2021
eng
Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2), is a severe infection with respiratory and systemicmanifestations. This infectious disease has a complex course and manifests itself withvarious clinical presentations, ranging from asymptomatic infection to a severe clinicalcourse. These variations in severity have raised the question of whether the genetic orepigenetic variations have a role in COVID-19 susceptibility or severity, and that thesefactors can be used to predict the disease course. A whole-genome sequencing performedon 95 samples of SARS-CoV-2 identified 116 unique mutations, most of which weremissense and synonymous. Moreover, some studies have reported a relationship betweenthe COVID-19 severity and the genes ACE and TMPRSS2. The present review providesan overview of different genes that have been found to be implicated or related to thesusceptibility to COVID-19 or its severity.
Personalized Medicine Journal
AmitisGen TECH Dev Group
2476-5538
6
v.
21
no.
2021
17
22
https://www.pmjournal.ir/article_244730_31b7d1361df9f341d51df05f9845d346.pdf
dx.doi.org/10.22034/pmj.2021.244730
The application of DNA-conjugated gold nanoparticles to detect metabolites and nucleic acids in personalized medicine
Roya
Amirinejad
Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
author
Zeinab
Shirvani-Farsani
Department of Cell and Molecular Biology, Faculty of Biological Sciences and Technology, Shahid Beheshti University G.C., Tehran, Iran
author
Sohameh
Mohebbi
Department of Biotechnology, Faculty of Basic Science, Ale-Taha Institute of Higher Education, Tehran, Iran.
author
text
article
2021
eng
In this article, the features of DNA-functionalized goldnanoparticles (GNRs), including the size-dependent color, the amount of conjugated DNA, and the fluorescence quenchers will be described. DNA and aptamer conjugated GNRs can be applied for producing the colorimetric and fluorescent biosensors to detect all types of disease markers including DNA, RNA, protein and other small molecular metabolites.The early phase of this work is performed in clean buffers and serum samples. DNA-conjugated GNRs delivery into the cells is recently used for intracellular diagnosis in personalized medicine. Simultaneously, DNA-functionalized GNRs can be used to deliver the antisense DNA for gene therapy applications.With targeting both diagnosis and treatment applications, DNA- functionalized GNRs can be used as a suitable approach to reach theranostics purposes (diagnosis and treatment in a simultaneous manner).
Personalized Medicine Journal
AmitisGen TECH Dev Group
2476-5538
6
v.
21
no.
2021
23
25
https://www.pmjournal.ir/article_244733_088ba15a1b3e392b8849ead98e645ae6.pdf
dx.doi.org/10.22034/pmj.2021.244733