@article { author = {Ghasemzadeh, Abbas and Esfahani, Vahidreza}, title = {Covid19 disease and the effect of genetic factors on its severity and weakness}, journal = {Personalized Medicine Journal}, volume = {6}, number = {21}, pages = {17-22}, year = {2021}, publisher = {AmitisGen TECH Dev Group}, issn = {2476-5538}, eissn = {2717-3860}, doi = {10.22034/pmj.2021.244730}, abstract = {Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2), is a severe infection with respiratory and systemicmanifestations. This infectious disease has a complex course and manifests itself withvarious clinical presentations, ranging from asymptomatic infection to a severe clinicalcourse. These variations in severity have raised the question of whether the genetic orepigenetic variations have a role in COVID-19 susceptibility or severity, and that thesefactors can be used to predict the disease course. A whole-genome sequencing performedon 95 samples of SARS-CoV-2 identified 116 unique mutations, most of which weremissense and synonymous. Moreover, some studies have reported a relationship betweenthe COVID-19 severity and the genes ACE and TMPRSS2. The present review providesan overview of different genes that have been found to be implicated or related to thesusceptibility to COVID-19 or its severity.}, keywords = {Covid19,ACE gene,TMPRSS2 gene,Infection}, url = {https://www.pmjournal.ir/article_244730.html}, eprint = {https://www.pmjournal.ir/article_244730_31b7d1361df9f341d51df05f9845d346.pdf} }