%0 Journal Article %T Titanium dioxide nanoparticles can induce apoptosis in cancer cells %J Personalized Medicine Journal %I AmitisGen TECH Dev Group %Z 2476-5538 %A Naghoosi, Hamed %A Saremi, Mohammad Ali %D 2020 %\ 12/01/2020 %V 5 %N 19 %P 16-18 %! Titanium dioxide nanoparticles can induce apoptosis in cancer cells %K Nanoparticle %K TiO2-NP %K Hepatocellular %K Apoptosis %R 10.22034/pmj.2020.240047 %X Nanotechnology involves the creation and manipulation of materials at nanoscale to create products that exhibit novel properties. Nano-TiO2, as one of the top five nanoparticles in annual production, is widely applied in industries ranging from healthcare to drug delivery. The properties of nanoTiO2 have raised concerns regarding toxicity. Annexin V-FITC/PI double staining and a flow cytometer were used to detect apoptosis. A significant increase in apoptosis was observed at concentrations of TiO2-NP of 50-100 µg/ml, varying between 25-40% apoptosis by 24 h. To further investigate the aptotic and toxic effects of these substances, it is recommended that this study be performed in the in vivo phase. %U https://www.pmjournal.ir/article_240047_8fc6127b281c9e6e5b2471714bd8bfb3.pdf