TY - JOUR ID - 246865 TI - The Tumor Microenvironment and its Role in Tumor Progression and Metastasis JO - Personalized Medicine Journal JA - PMJ LA - en SN - 2476-5538 AU - Gholami Fireh, Sepideh AU - Moosavi, Seyed Akbar AD - Msc molecular Genetics, Islamic Azad university Central Tehran Branch, Tehran, Iran AD - School of Paramedical Sciences, Iran University of Medical Sciences, Tehran, Iran Y1 - 2021 PY - 2021 VL - 6 IS - 22 SP - 16 EP - 22 KW - tumor microenvironment KW - Metastasis KW - Cancer KW - TME KW - Inflammation DO - 10.22034/pmj.2021.246865 N2 - Humans are continuously exposed to a wide of carcinogenic and mutagenic stimuli, including environmental toxins, radiation and viruses as well as other infections. Tumor metastasis is responsible for approximately 9% of all cancer related deaths. The tumor microenvironment (TME) contains many distinct cell types, including endothelial cells and their precursors, pericytes, smooth muscle cells, fibroblasts, carcinoma-associated fibroblasts, myofibroblasts, neutrophils, eosinophils, basophils, mast cells, T and B lymphocytes, natural killer cells and antigen presenting cells (APC) such as macrophages and dendritic cells. Recent evidence has shown that stromal tissue is much more than a passive bystander in the development and progression of cancers. None the lese,the clinical therapy for many types of human cancers has mainly focused on the malignant cancer cell itself, and have made great achievements, yet cancer therapy still remains a great challenge. This review highlights the evidence for the crucial role of the tumor microenvironment in tumor progression and metastasis. UR - https://www.pmjournal.ir/article_246865.html L1 - https://www.pmjournal.ir/article_246865_4a517013c6450e2852f79201f23e361b.pdf ER -