TY - JOUR ID - 249034 TI - Evaluation of LBX-2AS1 Gene Expression in Patients with Colorectal Cancer JO - Personalized Medicine Journal JA - PMJ LA - en SN - 2476-5538 AU - Raafat, Nermin AU - Makhseed, Nawal AD - Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine Zagazing University, Zagazing, Egypt AD - Department of Pediatrics, Al-Jahra Hospital, Ministry of Health, Al-Jahra City, Kuwait Y1 - 2021 PY - 2021 VL - 6 IS - 23 SP - 1 EP - 4 KW - Colorectal cancer KW - Long Non Coding RNA KW - Gene expression KW - LBX2-AS1gene DO - 10.22034/pmj.2021.249034 N2 - Colorectal Cancer (CRC) is the third most common cancer in Iranian men and the fourth most common cancer in women. Recent studies have shown that lncRNAs may also engage in remodeling the tumor microenvironment and tumor metastasis. A lncRNA called LBX2 antisense RNA 1 (LBX2-AS1) has been reported to exert crucial regulatory actions in various cancer. In this study, we evaluate the expression of LBX2-AS1gene in 30 colorectal cancer tumor samples. Gene expression was assessed by Real-time PCR method and the results were analyzed by 2^-DDct. relative expression of this gene in tumor samples compared to healthy samples showed a 1.4-fold increase in tumor samples. According to our findings in this study and the results of other studies, it can be concluded that this gene can be used as a therapeutic target. UR - https://www.pmjournal.ir/article_249034.html L1 - https://www.pmjournal.ir/article_249034_1937d615b3f4877c01b32a043d018d84.pdf ER -