TY - JOUR ID - 39041 TI - Association between CDKAL1 Gene Polymorphism and Risk of Type 2 Diabetes in Population of Lorestan Province JO - Personalized Medicine Journal JA - PMJ LA - en SN - 2476-5538 AU - Mohammadi Pour, Fatemeh AU - Imani Farahani, Faezeh AD - Personalized Medicine Research Center of AmitisGen, Tehran, Iran Y1 - 2019 PY - 2019 VL - 4 IS - 15 SP - 19 EP - 21 KW - Diabetes KW - gene polymorphism KW - T2DM KW - CDKAL1 KW - RFLP DO - 10.21859/pmj01037 N2 - Diabetes Mellitus is defined as a metabolic disorder characterized by chronic hyperglycemia. The more prevalent form, type 2 diabetes, usually begins as insulin resistance, a disorder in which the cells do not use insulin properly. T2DM is a complex multifactorial disease in which multiple genetic variants interact with environmental factors to trigger the disease. There is sufficient evidence that T2DM has a strong genetic basis. One of the identified candidate genes associated with type 2 diabetes is CDKAL1, reduced expression of CDKAL1 would result in enhanced activity of CDK5 in β cells, which would lead to decreased insulin secretion. In this study, the association of polymorphism rs10946398 of CDKAL1 with type 2 diabetes was evaluated in 200 people by RFLP-PCR method. No significant association was found between the genotypes of polymorphism rs10946398 and type 2 diabetes in the target population. It is suggested that this polymorphism association with type 2 diabetes in larger populations evaluated. UR - https://www.pmjournal.ir/article_39041.html L1 - https://www.pmjournal.ir/article_39041_85ef5219ed892f94f3fd1c595f79c816.pdf ER -