TY - JOUR ID - 40425 TI - Effects of iron oxide nanoparticles on MDA-MB-231 breast breast cell line JO - Personalized Medicine Journal JA - PMJ LA - en SN - 2476-5538 AU - Ibrahim, Ramadhan AU - Saremi, Mohammad Ali AU - Keshavarz Shahbaz, Mohammad Ali AU - forouhi, Maryam AD - Fish Recourses and Aquatic Animals Department, College of Agriculture Salahaddin University, Erbil, Iraq AD - Personalized Medicine Research Center of AmitisGen, Tehran, Iran AD - Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology, Tehran, Iran AD - National Institute of Genetic Engineering and Biotechnology, Tehran, Iran Y1 - 2020 PY - 2020 VL - 5 IS - 16 SP - 3 EP - 5 KW - Iron oxide nanoparticle KW - Oxidative stress KW - Reactive Oxygen Species KW - Breast cancer DO - 10.22034/pmj.2020.40425 N2 - Because of their small size, unique physics, and chemical properties, metal nanoparticles can easily cross obstacles and reach their target cells, which makes them an ideal choice for therapeutic purposes in various cancers. In this study, the effects of iron oxide nanoparticles on MDA-MB-231 breast cancer cell line were examined, and biomarkers related to oxidative stress were evaluated. Fe2O3 nanoparticles were suspended in a cell culture medium and diluted to appropriate concentrations (0, 10, 30, 60, and 120 μg/ml) for 24 and 48 h. GSH, superoxide dismutase, catalase, and ROS generation were evaluated. The results showed that iron oxide nanoparticles induced intracellular ROS generation in a dose- and time-dependent manner. The results further showed that iron oxide nanoparticles increased ROS and activated oxidative stress in cells. UR - https://www.pmjournal.ir/article_40425.html L1 - https://www.pmjournal.ir/article_40425_4144ab5b5ff97830c742e7cfb38da35e.pdf ER -