AmitisGen TECH Dev GroupPersonalized Medicine Journal2476-553872420220320The Role of DNA Methylation in Development and Progression of Rheumatoid Arthritis1725243810.22034/pmj.2022.252438ENFawziah MohammedMedical Laboratory Sciences.Faculty of Allied Health Sciences, Kuwait
University. Kuwait.Seyed Akbar MoosaviSchool of Paramedical Sciences, Iran University of Medical Sciences, Tehran, IranJournal Article20220110Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology that results in progressive joint destruction and ultimately to disability. Currently effective biologic therapies, exist for approximately 40% of patients, but disease activity remains inadequately controlled in others. Therefore, it is crucial to identify specific markers that predict therapeutic response in various patients, prior to the initiation of therapy. DNA methylation , as a epigenetic factor, is increasingly being explored as a potential theranostic biomarker. It has been suggested that DNA methylation might contribute to RA development, nonetheless , with conflicting results. Epigenetic modules have provided a possible interface through which genetic and environmental risk factors contribute to the susceptibility and pathogenesis of RA. Hence, epigenetic regulators may provide promising drug targets to develop novel therapeutic drugs for tailored treatment of RA patients. Here we review the current knowledge regarding the role of DNA methylation in RA and indicate its potential therapeutic implications.https://www.pmjournal.ir/article_252438_b56c1b69d5ad7743d98bc225de7deec4.pdfAmitisGen TECH Dev GroupPersonalized Medicine Journal2476-553872420220320Epithelial-Mesenchymal Rransition and its Role in Breast Cancer Metastasis81325243910.22034/pmj.2022.252439ENAvan Saeed MohammedDepartment of Biology, College of Science, University of Duhok, Duhok,Iraq.Ghazal GhajariDepartment of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, IranJournal Article20211228Breast cancer is the most common cancer in women and distant site metastasis is the main cause of death in breast cancer patients. Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. EMT is a vital process for large-scale cell movement during morphogenesis at the time of embryonic development. Tumor cells usurp this developmental program to execute the multi-step process of tumorigenesis and metastasis. Understanding the biological intricacies of the EMT may provide important insights that lead to the development of therapeutic targets in pre-invasive and invasive breast cancer, and could be used as biomarkers for identifying tumor subsets with greater chances of recurrence, metastasis, and therapeutic resistance leading to death. The purpose of this article is to investigate the association between EMT and breast cancer.https://www.pmjournal.ir/article_252439_fad60727a5de75be655dc9faff1121c1.pdfAmitisGen TECH Dev GroupPersonalized Medicine Journal2476-553872420220320Androgens in Prostate Cancer: A Review Article141825244010.22034/pmj.2022.252440ENNazar ShabilaDepartment of Community Medicine, Hawler Medical University,
Erbil, Iraq.Ghasem Ghorbani Vale ZaghardDepartment of molecular genetics, Ahar Branch, Islamic Azad university, Ahar, IranJournal Article20220106Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer. Clinical treatments that target steroidogenesis and the androgen receptor (AR) successfully postpone disease progression. The role of androgens and AR signaling has been well characterized in metastatic prostate cancer, where it has been shown that prostate cancer cells are exquisitely adept at maintaining functional AR signaling to drive cancer growth. This review summarizes the current information regarding the role of androgens in prostate cancer.https://www.pmjournal.ir/article_252440_609274a466c91e612712f250eec9424b.pdfAmitisGen TECH Dev GroupPersonalized Medicine Journal2476-553872420220320miR-22-3p as a Novel Biomarker in Rheumatoid Arthritis192225247910.22034/pmj.2022.252479ENMaryam HassanpoorDepartment of cell and molecular biology,Faculty of biological sciences,
Kharazmi university, Tehran, IranBahareh AbbasiNational Institute of Genetic Engineering and Biotechnology.Journal Article20220114Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune. Early diagnosis of RA remains challenging. A significant portion of RA patients also experience unremitting symptoms despite treatment. miRNA are involved in the regulation of autoimmunity- and inflammation-related processes. In this study, we evaluated the expression of miR-22-3p in serum of RA patients as a novel biomarker. Expression level of this gene in the blood serum of 30 people with RA compared with 30 healthy individuals by the qRT-PCR method. Results showed levels of miR22-3p were significantly higher in the serum of patients with RA in comparison with healthy control (p<0.0001). We suggest that miR 22-3p can be used as a biomarker in early detection and screening.https://www.pmjournal.ir/article_252479_f612076e20e0cef7b8643387a9bbb545.pdfAmitisGen TECH Dev GroupPersonalized Medicine Journal2476-553872420220320Investigating the Link Between MS and the EBV Virus232725244110.22034/pmj.2022.252441ENBahareh AbbasiNational Institute of Genetic Engineering and Biotechnology.Almas AraghiDepartment of Microbiology, Faculty of Biological Sciences, North Tehran Islamic Azad University, Tehran, Iran.AmirHossein Akbari AghababaDepartment of Microbiology, Faculty of Biological Science, North Branch, Islamic Azad University, Tehran, IranJournal Article20220109Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Epstein–Barr virus (EBV) is a human DNA herpesvirus infecting more than 90% of the world's population. EBV is the etiological agent of infectious mononucleosis (Pfeiffer's disease). Major predisposing factors for MS are certain tissue types (e.g., HLA DRB1*15:01), vitamin D deficiency, smoking, obesity, and infection with Epstein-Barr virus (EBV). This review summarizes current knowledge on the association between EBV and MS.https://www.pmjournal.ir/article_252441_d8b67508f0643c85eee7e10f4f61577d.pdfAmitisGen TECH Dev GroupPersonalized Medicine Journal2476-553872420220320A Review of the Role of Exosomes in Prostate Cancer283225244210.22034/pmj.2022.252442ENRafid A AbdulkareemGenetic engineering and biotechnology Institute, Baghdad University, Iraq.Seyed Majid Hashemi FardAmitisGen Lab, Food and Drug Administration of Iran Ministry of Health and Medical Education. Tehran, IranMasoomeh KohandaniMaster of Science in Cellular and Molecular Biology, Department of cell and Molecular Biology, Karazmi University, Tehran, IranJournal Article20220110Prostate cancer (PCa) is the most common solid tumor in men. While patients with local PCa have better prognostic survival, patients with metastatic PCa have relatively high mortality rates. Exosomes (and other extracellular vesicles) are now part of the cancer research landscape, involved both as players in pathophysiological mechanisms, as biomarkers of the cancer process, and as therapeutic tools. Exosomes contain miRNAs, mRNAs, and proteins with the potential to regulate signaling pathways in recipient cells. Accumulating evidence indicates that exosomes play important roles in cell communication and tumor progression and are suitable for monitoring PCa progression and metastasis.https://www.pmjournal.ir/article_252442_0849ce292fe9b259f0be4ffdc9804bc4.pdf