investigation the correlation between FGL1 expression and prognosis in gastric cancer patients

Document Type : Original Article

Authors

1 Reference health laboratory, Ministry of health and medical education

2 Department of Cellular and Molecular, Faculty of Life Sciences, North Tehran Branch, Islamic Azad University, Faculty of Biological Sciences, Tehran, Iran

10.22034/pmj.2020.240044

Abstract

Gastric cancer is the fourth most common cancer worldwide and it ranks second among cancer deaths. Several studies have shown that FGL2 contributes to the pathogenesis of a number of infectious diseases, However, little is known about its biological functions in cancer development and metastasis. In this study, we investigated the correlation between FGL1 expression and prognosis in GC patients. gastric  cancer tissue  and adjacent healthy pecimens (n=20) were obtained from patients aged between 30 and 50 years who were diagnosed with in gastric cancer, Total RNA was extracted, Reverse transcription and qPCR was performed and Relative expression level was calculated using the 2-∆∆Cq  method. We found that the expression of FGL1 in gastric cancer tissues were obvi­ously higher than that in the adjacent tissues at mRNA levels (p <0.003).

Keywords