1
Kermanshah University of Medical Sciences, School of the Medicine, Kermanshah, Iran
2
Personalized Medicine Research Center of AmitisGen, Tehran, Iran
10.22034/pmj.2020.240046
Abstract
Cervical cancer is the most widely screened cancer in the world both in high- and middle-income countries. HPV has been implicated in 99.7% of cervical squamous cell cancer cases worldwide. Viral E6 and E7 genes expression leads to alterations of the cellular genome integrity, including structural and numerical chromosomal instability resulting in chromosomal mis-segregation and aneuploidy. Centromere protein M (CENPM) is an essential centromere component for chromosome separation. In this study, we evaluated the expression of this gene at mRNA level by qRT-PCR method on 20 cancer samples who previously had feather papillomavirus infection, The results show a significant increase in the expression of this gene in cancer samples.
Amuzgar, R., Shojaei, N. (2020). Evaluation of CENPM gene expression in cervical cancer. Personalized Medicine Journal, 5(19), 13-15. doi: 10.22034/pmj.2020.240046
MLA
Raziye Amuzgar; Najme Shojaei. "Evaluation of CENPM gene expression in cervical cancer". Personalized Medicine Journal, 5, 19, 2020, 13-15. doi: 10.22034/pmj.2020.240046
HARVARD
Amuzgar, R., Shojaei, N. (2020). 'Evaluation of CENPM gene expression in cervical cancer', Personalized Medicine Journal, 5(19), pp. 13-15. doi: 10.22034/pmj.2020.240046
VANCOUVER
Amuzgar, R., Shojaei, N. Evaluation of CENPM gene expression in cervical cancer. Personalized Medicine Journal, 2020; 5(19): 13-15. doi: 10.22034/pmj.2020.240046