Titanium dioxide nanoparticles can induce apoptosis in cancer cells

Document Type : Original Article

Authors

1 Research Center for Cancer Epidemiology and Screening, Aja University of Medical Sciences, Tehran, Iran and Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran

2 Personalized Medicine Research Center of AmitisGen, Tehran, Iran

10.22034/pmj.2020.240047

Abstract

Nanotechnology involves the creation and manipulation of materials at nanoscale to create products that exhibit novel properties. Nano-TiO2, as one of the top five nanoparticles in annual production, is widely applied in industries ranging from healthcare to drug delivery. The properties of nanoTiO2 have raised concerns regarding toxicity. Annexin V-FITC/PI double staining and a flow cytometer were used to detect apoptosis. A significant increase in apoptosis was observed at concentrations of TiO2-NP of 50-100 µg/ml, varying between 25-40% apoptosis by 24 h. To further investigate the aptotic and toxic effects of these substances, it is recommended that this study be performed in the in vivo phase.

Keywords

Personalized Medicine Journal
Volume 5, Issue 19
original article
Autumn 2020
Pages 16-18

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