Document Type : Original Article

Authors

1 Department of genetic, Tehran-North branch, Islamic azad university, Tehran, Iran

2 Department of biology, Tehran-east branch, Islamic azad university, Tehran, Iran

3 Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran

Abstract

Warning of the World Health Organization (WHO) indicates that novel coronavirus (COVID-19) is pandemic and causes global concern. COVID-19 has acute respiratory symptoms which leads to die in many cases through the world. We have found seven variants in 300 patients based on Next Generation Sequencing (NGS) which are related to infectious disease. According to the databases, we confirmed that rs2660 and rs1800450 have association with COVID-19 in the Iranian population.

Keywords

1. Gao GFJC. From “A” IV to “Z” IKV: attacks from emerging
and re-emerging pathogens. 2018;172(6):1157-9.
2. Pauls SJTMBoC. Masters. 2006;66:193-292.
3. Fung TS, Liu DXJArom. Human Coronavirus: Host-Pathogen
Interaction. 2019;73:529-57.
4. Tesini BJM, University of Rochester School of Medicine,
Dentistry. Coronaviruses and Acute Respiratory Syndromes
(COVID-19, MERS, and SARS). 2020.
5. Fish I, Boissinot SJI. Contrasted patterns of variation and
evolutionary convergence at the antiviral OAS1 gene in old world
primates. 2015;67(9):487-99.
6. Hovanessian AGJC, reviews gf. On the discovery of interferon-
inducible, double-stranded RNA activated enzymes: The
2′–5′ oligoadenylate synthetases and the protein kinase PKR.
2007;18(5-6):351-61.
7. Melchjorsen J, Kristiansen H, Christiansen R, Rintahaka
J, Matikainen S, Paludan SR, et al. Differential regulation of
the OASL and OAS1 genes in response to viral infections.
2009;29(4):199-208.
8. Samuel CEJCmr. Antiviral actions of interferons.
2001;14(4):778-809.
9. Lin Y, Su C, Niu J, Guo Z, Cai LJJoe. Impact of mannose-
binding lectin 2 polymorphism on the risk of hepatocellular
carcinoma: a case-control study in Chinese Han population.
2015:JE20140194.
10. Zhang H, Zhou G, Zhi L, Yang H, Zhai Y, Dong X, et al.
Association between mannose-binding lectin gene polymorphisms
and susceptibility to severe acute respiratory syndrome
coronavirus infection. 2005;192(8):1355-61.
11. He J, Feng D, de Vlas SJ, Wang H, Fontanet A, Zhang P, et
al. Association of SARS susceptibility with single nucleic acid
polymorphisms of OAS1 and MxA genes: a case-control study.
2006;6(1):106.
12. Ezekowitz RAJTJoid. Role of the mannose-binding lectin in
innate immunity. 2003;187(Supplement_2):S335-S9.
13. Ip WE, Chan KH, Law HK, Tso GH, Kong EK, Wong WH, et
al. Mannose-binding lectin in severe acute respiratory syndrome
coronavirus infection. 2005;191(10):1697-704.