Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer. Clinical treatments that target steroidogenesis and the androgen receptor (AR) successfully postpone disease progression. The role of androgens and AR signaling has been well characterized in metastatic prostate cancer, where it has been shown that prostate cancer cells are exquisitely adept at maintaining functional AR signaling to drive cancer growth. This review summarizes the current information regarding the role of androgens in prostate cancer.