Document Type : Original Article

Authors

• Hadi Yari ¹
• kazhaleh Mohammadi ²
• Mohammad Ali Keshavarz Shahbaz ³
• Vahid Reza Esfahani ⁴

¹ Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology, Tehran, Iran.

² Researcher and lecture assistant at the Medical Laboratory Science Department, Knowledge University, Kurdistan Region, Erbil, Iraq

³ Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology, Tehran, Iran

⁴ Personalized Medicine Research Center of AmitisGen, Tehran, Iran

Abstract

The miRNAs produced predominantly in the placenta are probably involved in placental differentiation and maintenance of pregnancy. One of the important functions of miR-126 is its involvement in angiogenesis by enhancing the expression of VEGF. Abnormalities of placental vasculature may result in several gestational complications, including pregnancy loss. The current study compared the expression of miR-126 in the plasma of women with recurrent miscarriages and women with healthy pregnancies by Realtime qRT-PCR. The results indicated that the expression difference of miR-21 between the pregnant patients and the controls was statistically significant (p =0.002). This microRNA can be used as a biomarker in diagnosis and progression.

Keywords

• microRNA
• recurrent pregnancy loss
• gene expression
• Realtime qRT-PCR