Personalized Medicine Journal

Original Article

1. Role of personalized microRNA-124 Expression in Ovarian Cancer

Babak Otoukesh; Peyman Kaghazian; Amirjouya Talaei; Bahram Boddouhi; Bahareh Heshmat

Volume 4, Issue 13 , Spring 2019, Pages 1-5

http://dx.doi.org/10.21859/pmj04011

Abstract

Introduction: MicroRNA-124 (miR-124) is moderated in some human malignancies and is associated with tumor advancement. But, its expression and clinical importance in ovarian carcinoma ... Read More Introduction: MicroRNA-124 (miR-124) is moderated in some human malignancies and is associated with tumor advancement. But, its expression and clinical importance in ovarian carcinoma is still unclear. Thus, the goal of this study was to feature the clinical importance of personalized miR-124 expression in ovarian carcinoma. Methods: 94 women ovarian cancer tissues and 26 normal ovarian tissues were accumulated from patients. We used Real-time PCR to quantify the expression of personalized miR-124 in clinical ovarian carcinoma specimen and normal tissues. Moreover, we measured the miR-124 relationship with clinicopathologic characteristics and the ovarian carcinoma survival. Results: The lesser expression of miR-124 in tumor tissues can be found in compared with normal tissue using PCR method (P < 0.05). Our data exhibited that there is a notable association among low expression of miR-12 and clinical staging of ovarian carcinoma (P = 0.023). Nevertheless, miR-124 expression was not notably associated with age (P = 0. 671), differentiation status (P = 0.512), lymph node metastasis (P = 0.415) and histological subtypes (0.547). Kaplan-Meier survival analysis and log-rank test were applied in present study. These tests showed the less expression on patients had markedly short-term survival time in comparison with high expression group (P = 0.022). Multivariate Cox proportional hazards model analysis revealed that less expression of miR-124 and clinical staging were contribute to short-term survival in patients with ovarian carcinoma. The HR of the low miR-124 expression group was calculated to be 2.532 (95% CI: 1.572-9.237, P = 0.021), (clinical staging HR: 2.532; 95% CI: 1.321-9.241, P = 0.032). Conclusions: These findings suggested that personalized miR-124 could be considered as an independent prognostic factor for ovarian carcinoma patients. Our findings suggested that low expression of personalized miR-124 has prognostic worthiness in ovarian.

Original Article

2. Is History of Coronary Artery Bypass Graft Surgery a Strong Determinant of Inferiority of Organ in Cadaveric Liver Donation? Emerging Role of personalized Medicine

Meysam Mojtabaee; Saman Nikeghbalian; Shagin Shahryari; Siavash Gholami; Farahnaz Sadegh Beigee

Volume 4, Issue 13 , Spring 2019, Pages 6-7

http://dx.doi.org/10.21859/pmj04012

Abstract

Nowadays, there has been a considerable advance of personalized medicine on ascientific basis and clinical demands in cardiovascular diseases. This study investigateda history of coronary ... Read More

Original Article

3. Personalized Medicine Journal in 2019: Reflecting on the Development of the Upcoming Role of Personalized Medicine in the Therapies

Massoud Houshmand; Seyed Hassan Saadat

Volume 4, Issue 13 , Spring 2019, Pages 8-9

http://dx.doi.org/10.21859/pmj04013

Abstract

In recent decades, there has been an increase in the incidence of cancer in the affected communities. However, the growth of therapeutic strategies has been very slow. Conventional ... Read More

Original Article

4. Clinical Significance and Seroprevalence of L. monocytogenesin in Pregnant Women with Spontaneous Abortion: Personalized Medicine to Improve Outcome (Diagnosis and Monitoring)

Mahsa Mozaffari; Mohamad Mozafari; Mahdi Mohebbi

Volume 4, Issue 13 , Spring 2019, Pages 10-13

http://dx.doi.org/10.21859/pmj04014

Abstract

Introduction: Recent scientific promotion reveals that medicine is currently at a transition stage from programmatic to personalized handling on in infectious diseases. Methods: Herrien, ... Read More

Original Article

5. Evaluation of Personalized Medicine for Patients with Brain and Spinal Cord Injury using the Nigella sativa L. Seed: An Updated Comprehensive and Critical Review

Babak Otoukesh; Peyman Kaghazian; Bahram Boddouhi; Bahareh Heshmat; Maria Kaghazian

Volume 4, Issue 13 , Spring 2019, Pages 14-18

http://dx.doi.org/10.21859/pmj04015

Abstract

Introduction: Nigella sativa (NS) is a widely used medicinal plant and appears to have a general health protective effect. As has been reported previously, pharmacological actions of ... Read More Introduction: Nigella sativa (NS) is a widely used medicinal plant and appears to have a general health protective effect. As has been reported previously, pharmacological actions of NS have been explored including antidiabetic, anticancer, immunomodilative, analgesic, anti-inflammatory, spasmolytic, bronchodilator, hepatoprotective, renal protective, antioxidant properties, gastroprotective, antihistaminic, antibacterial, neuroprotective and antioxidative effects and etc. Methods: The present review aimed to give a personalized care for patients using detailed survey of the literature on and neuroprotective activities of the plant. Pubmed, Science Direct, Google scholar and Springer databases were searched from 1983 till January 2015. Key words were included: N. sativa, black seed, neuropathy, neuroprotective, brain and spinal injury, thymoquinone and posttrauma. Searching was limited to articles with English language. Review articles, case reports, abstract in symposium and congress, studies on N. sativa mixed with other plants were excluded. This study thus launches a huge resource for understanding the role of NS in in brain and spinal cord tissue damage after trauma with broad relevance for personalized medicine. Results: Results indicated that based on personalized medicine many of the herbal attributes of the herbal are due to the thymoquinone presence as its bioactive component, and therapy with NS notably decreased post-traumatic degenerative neurons and distorted nerve cells were not primarily treated in NS rats. In conclusion, NS can improve neuropathic status and neurological dysfunctions in the brain and spinal injury models. However, more clinical trials are necessary to clarify beneficial effects of NS its effective type and dosage for neuropathies management and its complications. Conclusions: Finally, NS treatment might be effective in detrimental the cerebral and spinal cord after trauma as personalized care for patients, and therefore shows potential for clinical implications.

Original Article

6. Investigation of Toxoplasma gondii in Pregnant Women: A Strategy for Personalized Medicine

Mahsa Mozaffari; Mohamad Mozafari; Morvarid Otoukesh; Mohammad Ghaemi; Mahdi Mohebbi

Volume 4, Issue 13 , Spring 2019, Pages 19-22

http://dx.doi.org/10.21859/pmj04016

Abstract

Introduction: In this study, we evaluated the Seroepidemiology of T. gondii among470 pregnant women as well as association of infection with socio-demographic factors and risk factors ... Read More

Original Article

7. Impact of diseased Donors’ Serum Creatinine Level on Outcome of transplanted Kidneys: The Use of Personalized Medicine for Patient Selection

Meysam Mojtabaee; Fariba Ghorbani; Farahnaz Sadegh Beygi

Volume 4, Issue 13 , Spring 2019, Pages 23-25

http://dx.doi.org/10.21859/pmj04017

Abstract

Introduction: One of the possibilities is the utilize of personalized medicine, a method based on quantifiable and theoretical agents that assign the worldwide immunological hazard ... Read More Introduction: One of the possibilities is the utilize of personalized medicine, a method based on quantifiable and theoretical agents that assign the worldwide immunological hazard of refusal for each patient. Kidney transplantation is the best treatment for end-stage renal disease patients. Although the shortage of kidneys for transplantation has been addressed by expanding the criteria, transplantation teams in Iran don’t have great tendency to implant marginal organs from brain death donors specially the ones with high creatinine before harvesting. The aim of this study was to evaluate the impact of brain dead donor serum creatinine (Cr) level on outcome of transplanted kidneys. Methods: In this retrospective study, the records of 46 brain-dead donors of Masih Daneshvari organ procurement unit of Tehran, Iran were assessed. The medical file of donated 58 recipients was available. Donor demographic data (age, sex), brain death cause and the Cr level after transferring to OPU ICU were recorded. The Cr level was categorized based on ≥1.4 mg/dl with origin of prerenal azotemia or lower. The urine output of transplanted patients in the first 24 hours post-transplant, serum Cr level at discharge from hospital and dialysis during first month after transplantation were compared between two groups. Results: The mean age of donors was 37yr and 25 (54%) were male. The cause of brain death in 16 (35%) was trauma. The donors’ creatinine level at the admission to the ICU was 1.4mg/dl or higher in 20 (35%). The first 24 hours urine output did not significantly differ between donors’ creatinine level lower than 1.4mg/dl or higher (5500 ± 2678ml and 4068 ± 3399ml, respectively, P=0.083). Similarly the recipient discharge serum Cr level did not significantly differ between two groups (1.69 ± 0.97 and 1.74 ± 1.34 mg/dl, respectively, P=0.887). Overall 8 recipients (14%) needed dialysis during first month after transplantation and there was no significant difference between groups (11% and 20%, respectively, P = 0.320). Conclusions: Findings of this preliminary study showed that the outcome of transplanted kidneys from brain-dead donors with Cr level >=1.4mg/dl is similar to other patients. So, higher creatinine level is not a good excuse for rejecting the kidneys for transplantation. Because of various confounding factors in the assessment of transplanted kidney outcome, the future studies with larger sample size and longer follow-up period is recommended.

Personalized Medicine Journal

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Volume & Issue: Volume 4, Issue 13, original article, Spring 2019, Pages 1-32

1. Role of personalized microRNA-124 Expression in Ovarian Cancer

Abstract

2. Is History of Coronary Artery Bypass Graft Surgery a Strong Determinant of Inferiority of Organ in Cadaveric Liver Donation? Emerging Role of personalized Medicine

Abstract

3. Personalized Medicine Journal in 2019: Reflecting on the Development of the Upcoming Role of Personalized Medicine in the Therapies

Abstract

4. Clinical Significance and Seroprevalence of L. monocytogenesin in Pregnant Women with Spontaneous Abortion: Personalized Medicine to Improve Outcome (Diagnosis and Monitoring)

Abstract

5. Evaluation of Personalized Medicine for Patients with Brain and Spinal Cord Injury using the Nigella sativa L. Seed: An Updated Comprehensive and Critical Review

Abstract

6. Investigation of Toxoplasma gondii in Pregnant Women: A Strategy for Personalized Medicine

Abstract

7. Impact of diseased Donors’ Serum Creatinine Level on Outcome of transplanted Kidneys: The Use of Personalized Medicine for Patient Selection

Abstract