Original Article
Analysis of EGFR gene mutations in tissue samples of lung cancer tumors
1. Analysis of EGFR gene mutations in tissue samples of lung cancer tumors

Blnd Ibrahim Mohammed; Amir Mohammadi; Nafise Poorhasan

Volume 5, Issue 17 , Spring 2020, Pages 1-4

http://dx.doi.org/10.22034/pmj.2020.43451

Abstract
  Lung cancer is the leading cause of cancer deaths worldwide. Approximately 25% of nonsmall-cell lung cancers have mutations in the EGFR gene, most of which occur in hotspot regions ...  Read More
Original Article
Comparison of different methods of DNA extraction from paraffin-embedded tissues
2. Comparison of different methods of DNA extraction from paraffin-embedded tissues

Ramadhan Ibrahim; Saeed Megdadi; Sareh Bakhshandeh bavarsad; Najme Shojaei

Volume 5, Issue 17 , Spring 2020, Pages 5-8

http://dx.doi.org/10.22034/pmj.2020.43452

Abstract
  The most common human archival specimens are formalin-fixed and paraffin-embedded tissues. PCR-based techniques have been coupled with new developments in the extraction of DNA from ...  Read More
Evaluation of V617F JAK 2 gene mutation by high resolution Melting method in patient witherythrocytosis
3. Evaluation of V617F JAK 2 gene mutation by high resolution Melting method in patient witherythrocytosis

Fawziah M. Mohammed; Hossein Pakzad; Vahid Reza Esfahani

Volume 5, Issue 17 , Spring 2020, Pages 9-11

http://dx.doi.org/10.22034/pmj.2020.43453

Abstract
  Although several techniques have been developed for the detection of JAK2 V617F mutation, these techniques have their disadvantages. High-resolution melting (HRM) analysis is a new, ...  Read More
Original Article
Increased expression of the lnc H19 gene in the plasma of people with breast cancer
4. Increased expression of the lnc H19 gene in the plasma of people with breast cancer

kazhaleh Mohammadi; Sadegh Shojaei Baghini; Mohammad Ali Saremi

Volume 5, Issue 17 , Spring 2020, Pages 12-14

http://dx.doi.org/10.22034/pmj.2020.43454

Abstract
  The majority of ncRNAs are known as long non-coding RNAs (lncRNAs) whose length exceeds 200 nucleotides. H19, a lncRNA, is the transcription product of the H19 gene, an oncogene in ...  Read More
Original Article
The effect of silver nanoparticles on MCF7 breast cancer cell
5. The effect of silver nanoparticles on MCF7 breast cancer cell

Abdulkarim Karim; Mohammad Ali Keshavarz Shahbaz; Afarin Komam

Volume 5, Issue 17 , Spring 2020, Pages 15-17

http://dx.doi.org/10.22034/pmj.2020.43455

Abstract
  Currently, little is known about the mechanism(s) of AgNP-induced toxicity. Many previous studies, however, have provided strong evidence for a link between the AgNP-mediated production ...  Read More
Original Article
Relationship between PAI1 promoter 4G/5g polymorphism and stroke
6. Relationship between PAI1 promoter 4G/5g polymorphism and stroke

Sahar Hassannejad; Ehsan Razeghian; Najme Shojaei

Volume 5, Issue 17 , Spring 2020, Pages 18-20

http://dx.doi.org/10.22034/pmj.2020.43456

Abstract
  PAI-1 has become recognized as a central molecule linking pathogenesis and progression of thrombotic vascular events, including stroke. Clinical and experimental studies show that PAI-1 ...  Read More
Original Article
Investigating the relationship between VEGF gene C936T-rs3025039 polymorphism and type 2 diabetes
7. Investigating the relationship between VEGF gene C936T-rs3025039 polymorphism and type 2 diabetes

Hadi Yari; Niloofar JAHANGIR SOOLTANI; Mohammad Ali Saremi

Volume 5, Issue 17 , Spring 2020, Pages 21-24

http://dx.doi.org/10.22034/pmj.2020.43457

Abstract
  Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is characterized by high blood sugar, insulin resistance, and relative lack of insulin.Diabetic retinopathy, a secondary ...  Read More