Personalized and Precision Medicine Journal

Abstract This review synthesizes and elaborates on current studies examining the neurotoxic effects of microplastics, emphasizing their mechanisms of entry into the central nervous system and their possible involvement in the development of neurodegenerative disorders. The pervasive presence of microplastics in the environment has heightened concerns about their accumulation in biological systems, particularly their capacity to traverse biological boundaries and engage with neuronal tissues. This article seeks to synthesize and critically evaluate the existing scientific literature on microplastic neuroinvasion, concentrating on the mechanisms through which these particles penetrate the blood-brain barrier (BBB) specifically via transcellular, paracellular, or Trojan horse pathways—and their ensuing effects on neuronal homeostasis.

We investigate the physiological and molecular reactions triggered by microplastics, encompassing oxidative stress induction, mitochondrial failure, neuroinflammation, and synaptic disruption. These pathogenic processes may facilitate the onset and advancement of several neurodegenerative disorders, including Alzheimer’s disease, by intensifying amyloid-beta aggregation, tau phosphorylation, and neuroimmune activation. Additionally, we examine the burgeoning epidemiological and experimental evidence associating microplastic exposure with cognitive deterioration and neuronal impairment.

This review offers a thorough analysis of microplastic neurotoxicity by evaluating both in vitro and in vivo studies, with the objective of elucidating the potential neurological hazards associated with these environmental contaminants. We emphasize significant deficiencies in existing research and propose future avenues, encompassing enhanced detection techniques, public health initiatives, and efforts to reduce human exposure to microplastics.

Abstract Alzheimer's disease (AD) is a neurodegenerative disease that leads to progressive and incurable cognitive and behavioral disorders. Personalized medicine, which is also called precision medicine, represents an approach to the treatment of the disease with the aim of improving the effectiveness of the treatment, which stops or slows the disease in an optimal and targeted manner based on a certain time. It enables physician to accurately and efficiently identify the most effective treatment. Personalized medicine is based on molecular knowledge. Genome sequencing by the Human Genome Project (HGP) represents one of the most powerful tools for personalized medicine, as well as transcriptomics, proteomics and metabolomics development which can be used for both disease prediction and better treatment. In this paper, we will review the strategies that personalized medicine offers for the treatment of AD for the future.