Personalized and Precision Medicine Journal

Abstract ABSTRACT
Brucellosis, a zoonotic disease caused by Brucella species, remains endemic in regions such as Iran and presents significant public health challenges. Conventional antibiotic therapies have limitations, including adverse effects and incomplete efficacy, which has led to growing interest in medicinal plants as complementary or alternative treatments. This study reviews Iranian medicinal plants with potential anti-brucellosis activity, examining their mechanisms based on both traditional knowledge and contemporary scientific research. A comprehensive literature search was conducted using keywords including "brucellosis," "Malta fever," "traditional medicine," "medicinal plants," and "treatment" in databases such as Google Scholar, SID, Magiran, and Scopus. Relevant articles were screened, and data were systematically extracted and analyzed to provide an integrative review. The analysis identified several medicinal plants with notable therapeutic potential against brucellosis, including Zingiber officinale Roscoe, Mentha piperita L., Cinnamomum verum J. Presl, Thymus vulgaris L., Salvia officinalis L., Origanum vulgare L., Matricaria chamomilla L., Aloe vera L., Cuminum cyminum L., Alcea rosea L., Achillea millefolium L., Calendula officinalis L., Allium cepa L., Anethum graveolens L., Apium graveolens L., Allium sativum L., Coriandrum sativum L., Cucurbita spp. L., Rosa canina L., Elaeagnus angustifolia L., Scrophularia deserti Eig, Berberis vulgaris L., Ziziphora tenuior L., and Alhagi maurorum Medik. Taxonomic analysis showed that the Lamiaceae family was most represented (24%), followed by Asteraceae and Apiaceae (16% each). Mechanistic analysis indicated that antibacterial activity accounted for 32% of therapeutic effects, followed by anti-inflammatory (24%) and antioxidant (20%) activities. Native Iranian medicinal plants may serve as effective complementary agents in the management of brucellosis. Their use, particularly in endemic regions, could enhance patients' quality of life and mitigate the side effects associated with conventional treatments. Nonetheless, further rigorous clinical studies are required to validate their efficacy and safety.

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology that results in progressive joint destruction and ultimately to disability. Currently effective biologic therapies, exist for approximately  40% of patients, but disease activity remains inadequately controlled in others. Therefore, it is crucial  to identify specific markers that predict therapeutic response in various patients, prior to the initiation of therapy.  DNA methylation , as a epigenetic factor, is increasingly being explored as a potential theranostic biomarker. It has been suggested that DNA methylation might contribute to RA development, nonetheless , with conflicting results. Epigenetic modules have provided a possible interface through which genetic and environmental risk factors  contribute to the susceptibility and pathogenesis of RA. Hence,  epigenetic regulators may provide promising drug targets to develop novel therapeutic drugs for tailored treatment of RA patients. Here we review the current knowledge regarding the role of DNA methylation in RA and indicate its potential therapeutic implications.

Abstract Introduction: Nigella sativa (NS) is a widely used medicinal plant and appears to have a general health protective effect. As has been reported previously, pharmacological actions of NS have been explored including antidiabetic, anticancer, immunomodilative, analgesic, anti-inflammatory, spasmolytic, bronchodilator, hepatoprotective, renal protective, antioxidant properties, gastroprotective, antihistaminic, antibacterial, neuroprotective and antioxidative effects and etc. Methods: The present review aimed to give a personalized care for patients using detailed survey of the literature on and neuroprotective activities of the plant. Pubmed, Science Direct, Google scholar and Springer databases were searched from 1983 till January 2015. Key words were included: N. sativa, black seed, neuropathy, neuroprotective, brain and spinal injury, thymoquinone and posttrauma. Searching was limited to articles with English language. Review articles, case reports, abstract in symposium and congress, studies on N. sativa mixed with other plants were excluded. This study thus launches a huge resource for understanding the role of NS in in brain and spinal cord tissue damage after trauma with broad relevance for personalized medicine. Results: Results indicated that based on personalized medicine many of the herbal attributes of the herbal are due to the thymoquinone presence as its bioactive component, and therapy with NS notably decreased post-traumatic degenerative neurons and distorted nerve cells were not primarily treated in NS rats. In conclusion, NS can improve neuropathic status and neurological dysfunctions in the brain and spinal injury models. However, more clinical trials are necessary to clarify beneficial effects of NS its effective type and dosage for neuropathies management and its complications. Conclusions: Finally, NS treatment might be effective in detrimental the cerebral and spinal cord after trauma as personalized care for patients, and therefore shows potential for clinical implications.