Personalized and Precision Medicine Journal

Abstract Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Epstein–Barr virus (EBV) is a human DNA herpesvirus infecting more than 90% of the world's population. EBV is the etiological agent of infectious mononucleosis (Pfeiffer's disease). Major predisposing factors for MS are certain tissue types (e.g., HLA DRB1*15:01), vitamin D deficiency, smoking, obesity, and infection with Epstein-Barr virus (EBV). This review summarizes current knowledge on the association between EBV and MS.

Abstract Warning of the World Health Organization (WHO) indicates that novel coronavirus (COVID-19) is pandemic and causes global concern. COVID-19 has acute respiratory symptoms which leads to die in many cases through the world. We have found seven variants in 300 patients based on Next Generation Sequencing (NGS) which are related to infectious disease. According to the databases, we confirmed that rs2660 and rs1800450 have association with COVID-19 in the Iranian population.

Abstract Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2), is a severe infection with respiratory and systemic
manifestations. This infectious disease has a complex course and manifests itself with
various clinical presentations, ranging from asymptomatic infection to a severe clinical
course. These variations in severity have raised the question of whether the genetic or
epigenetic variations have a role in COVID-19 susceptibility or severity, and that these
factors can be used to predict the disease course. A whole-genome sequencing performed
on 95 samples of SARS-CoV-2 identified 116 unique mutations, most of which were
missense and synonymous. Moreover, some studies have reported a relationship between
the COVID-19 severity and the genes ACE and TMPRSS2. The present review provides
an overview of different genes that have been found to be implicated or related to the
susceptibility to COVID-19 or its severity.

Abstract Introduction: Recent scientific promotion reveals that medicine is currently at a transition stage from programmatic to personalized handling on in infectious diseases. Methods: Herrien, this research was performed to evaluation seropositivity for L. monocytogenes based on personalized medicine among the women with and without annals of miscarriage by indirect immunofluorescence test (IIFA). Moreover, the relationship of seropositivity with demographic factors was also investigated. Results: Our outcome showed that 26.92% (35 cases) of women with an involuntary miscarriage were seropositive for L. monocytogenes, while 11% (11 cases) of healthy pregnant women were found positive for L. monocytogenes (P = 0.001). The most case of listeria has been found in age group of 30-35 years old, but no notable difference was found among different groups (P = 0.245). Moreover, there was a considerable association between listeria occurrence and history of abortion when compared with healthy pregnant women (P = 0.001). In addition, early abortion and the number of pregnancy were significantly linked to Listeria- seropositive in patients with spontaneous abortion (P = 0.041; P = 0.034). Conclusions: Further researches are required to appraise the clinical importance of L. monocytogenesin in pregnant women with symptomatic and asymptomatic infection related to personalized medicine.

Abstract Introduction: In this study, we evaluated the Seroepidemiology of T. gondii among470 pregnant women as well as association of infection with socio-demographic factors and risk factors such as age, and education was studied, which makes it a potential therapeutic option for personalized medicine. Methods: This cross sectional study was conducted among 470 pregnant women who presented to health centers from February 2013 to January 2014. Serum samples were prepared via a commercial ELISA kit (Euroimmun, Germany) for the attendance of IgG and IgM toxoplasma antibodies and the avidity of the IgG antibody based on the manufacturer’s protocol. Results: We found 34.4% of Toxoplasma IgG. Among 470 pregnant women, 166 cases positive for IgG antibodies toxoplasma were detected, showing a serum incidence of 35.31% (95% confidence interval 27.8 to 37.06%),and thirty eight (22.89%) out of 166 IgG-positive women revealed specific IgM antibodies. Conclusions: Our data showed that the prevalence of T. gondii infection is not related to age, gestational age, number of pregnancies, history of abortion, contact with soil, life in rural areas and education related to infection. as well as these findings may be of major interest for the select of the first-line anti-infection drug, and the urgent require for developing personalized medicine.