Personalized and Precision Medicine Journal

Abstract Recent research has uncovered a wide range of RNAs, including noncoding RNAs, and have discovered their varied modes of action inside cells. These ribonucleic acids (RNAs) play a crucial role in controlling many cellular processes and are thus anticipated to be significant targets for the treatment of human disorders. In recent years, RNA-based medicinal approaches have made significant advancements alongside their comprehensive functional research. Following extensive study and experimentation, medications based on antisense RNAs and small interfering RNAs have been successfully created and are already being used in clinical settings. Furthermore, there is now ongoing research focused on the development of pharmaceuticals using RNA aptamers and messenger RNA. In addition to the advancement of RNA-based medications, many techniques have been devised to effectively deliver RNA drugs into cells. RNA treatment offers several benefits compared to current therapeutics based on small molecules or monoclonal antibodies, mostly due to its ability to selectively target all genes inside cells. The purpose of this article is to provide an overview of the introduction of various RNA-based technologies and the introduction of RNA-based drugs in the market. In addition, the future prospects of RNA therapy will be addressed.

Abstract Multiple sclerosis (MS), the most common inflammatory demyelinating illness of the central nervous system (CNS), presents a range of clinical symptoms. The body’s immune system attacking myelin causes the transmission block in MS, which increases the electrical capacity of axons. Studies suggest that epigenetic factors play a part in the development of MS. Longer than 200 nucleotides in length and widely distributed, lncRNAs are linear RNA transcripts that cannot code for proteins. For instance, evidence suggests that lncRNAs are essential for a number of cellular functions, including immune response regulation, epithelial mesenchymal transition (EMT), cancer cell proliferation and metastasis, cellular homeostasis, and embryonic development. Epigenetic mechanisms have been proven to have a significant impact on the pathophysiology of MS, and their participation has revealed the function of lncRNAs as epigenetic regulatory molecules in molecular processes. The major subjects of this study have been the relationship between lncRNAs and MS, the role of lncRNA in the pathophysiology of the disease, and the diagnostic and prognostic potential of lncRNA in MS.