Abbas Ghasemzadeh; Vahidreza Esfahani
Abstract
Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2), is a severe infection with respiratory and systemicmanifestations. This infectious disease has a complex course and manifests ...
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Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2), is a severe infection with respiratory and systemicmanifestations. This infectious disease has a complex course and manifests itself withvarious clinical presentations, ranging from asymptomatic infection to a severe clinicalcourse. These variations in severity have raised the question of whether the genetic orepigenetic variations have a role in COVID-19 susceptibility or severity, and that thesefactors can be used to predict the disease course. A whole-genome sequencing performedon 95 samples of SARS-CoV-2 identified 116 unique mutations, most of which weremissense and synonymous. Moreover, some studies have reported a relationship betweenthe COVID-19 severity and the genes ACE and TMPRSS2. The present review providesan overview of different genes that have been found to be implicated or related to thesusceptibility to COVID-19 or its severity.
