Personalized and Precision Medicine Journal

Abstract Cancer, the second foremost worldwide cause of mortality, affects individuals both physically and emotionally. Traditional therapies, including surgery, chemotherapy, and radiation, have detrimental consequences, necessitating the pursuit of more targeted methods. Precision medicine facilitates more tailored therapies. The introduction of next-generation sequencing technology, as well as the growing frequency of large-scale tumor molecular profiling programs throughout the world, have changed cancer diagnosis and treatment. With the increasing availability of comprehensive genetic tests in medical and scientific settings, healthcare practitioners face complex hurdles in understanding and translating data. The article encapsulates the existing and forthcoming strategies for the implementation of precision cancer therapy, emphasizing the obstacles and potential ways to enhance the understanding and optimize the therapeutic value of molecular profiling outcomes.

Abstract We present a Non-Small Cell Lung Cancer Grade IV patient, diagnosed at 46 years of age, with multiple relapse from the diagnosis and demonstrating a poor prognosis after 3 cycles of treatments. A clinical comprehensive genomic profile was performed with the goal of finding potential actionable molecular alterations. The patient showed significant symptomatic and laboratory improvement with a combination chemotherapy determined by the molecular profiling, which would otherwise not have been considered. The mentioned approach was conducted since no other targeted therapies seemed actionable for him.