@article { author = {Houshmand, Massoud and Najeeb, Mohammed}, title = {Association of the KCNJ11 rs5219 E23K polymorphism with Type 2 Diabetes}, journal = {Personalized Medicine Journal}, volume = {5}, number = {19}, pages = {19-21}, year = {2020}, publisher = {AmitisGen TECH Dev Group}, issn = {2476-5538}, eissn = {2717-3860}, doi = {10.22034/pmj.2020.240048}, abstract = {Diabetes mellitus (DM) is a major public health issue in worldwide. Type 2 diabetes does not have a clear pattern of inheritance, although many affected individuals have at least one close family member, such as a parent or sibling, with the disease. The KCNJ11 gene is a member of the potassium channel gene family. polymorphisms  in KCNJ11  result  in  neonatal  diabetes and congenital hyper-insulinaemia, wherein the E23K (rs5219) polymorphism is linked with diabetes susceptibility where the K allele plays an important role in insulin secretion. In this study, we evaluate the frequency of these polymorphisms in a Kurdish population of 85 with type 2 diabetes. E23K polymorphism of KCNJ11 gene was genotyped by PCR-RFLP method. heterozygous carriers for AG are more in non‑diabetic patients (P = 0.034).}, keywords = {Diabetes Mellitus,single nucleotide polymorphism,PCR-RFLP,biomarker}, url = {https://www.pmjournal.ir/article_240048.html}, eprint = {https://www.pmjournal.ir/article_240048_c2cf1778ec4db1c0aa503c559c9fef72.pdf} }