%0 Journal Article %T A Case Report: The Potential Clinical Benefits of Comprehensive Molecular Profiling in an Aggressive NSCL Grade IV %J Personalized Medicine Journal %I AmitisGen TECH Dev Group %Z 2476-5538 %A Aliakbari, Elaheh %A Saremi, Mahnaz %D 2021 %\ 09/20/2021 %V 6 %N 22 %P 23-26 %! A Case Report: The Potential Clinical Benefits of Comprehensive Molecular Profiling in an Aggressive NSCL Grade IV %K EML4-ALK fusion %K TNM stage %K Erlotinib %K Osimertinib %K Next-generation sequencing %K Immunohistochemistry %R 10.22034/pmj.2021.246866 %X We present a Non-Small Cell Lung Cancer Grade IV patient, diagnosed at 46 years of age, with multiple relapse from the diagnosis and demonstrating a poor prognosis after 3 cycles of treatments. A clinical comprehensive genomic profile was performed with the goal of finding potential actionable molecular alterations. The patient showed significant symptomatic and laboratory improvement with a combination chemotherapy determined by the molecular profiling, which would otherwise not have been considered. The mentioned approach was conducted since no other targeted therapies seemed actionable for him. %U https://www.pmjournal.ir/article_246866_8c8de70a0aaf3068c5d70e6cf1cb6f0a.pdf