%0 Journal Article %T miR-22-3p as a Novel Biomarker in Rheumatoid Arthritis %J Personalized Medicine Journal %I AmitisGen TECH Dev Group %Z 2476-5538 %A Hassanpoor, Maryam %A Abbasi, Bahareh %D 2022 %\ 03/20/2022 %V 7 %N 24 %P 19-22 %! miR-22-3p as a Novel Biomarker in Rheumatoid Arthritis %K Rheumatoid arthritis (RA) %K Micro RNA %K miR 22-3p %K Gene expression %K Autoimmune Disease %R 10.22034/pmj.2022.252479 %X Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune. Early diagnosis of RA remains challenging. A significant portion of RA patients also experience unremitting symptoms despite treatment. miRNA are involved in the regulation of autoimmunity- and inflammation-related processes. In this study, we evaluated the expression of miR-22-3p in serum of RA patients as a novel biomarker. Expression level of this gene in the blood serum of 30 people with RA compared with 30 healthy individuals by the qRT-PCR method. Results showed levels of miR22-3p were significantly higher in the serum of patients with RA in comparison with healthy control (p<0.0001). We suggest that miR 22-3p can be used as a biomarker in early detection and screening. %U https://www.pmjournal.ir/article_252479_f612076e20e0cef7b8643387a9bbb545.pdf