TY - JOUR ID - 244730 TI - Covid19 disease and the effect of genetic factors on its severity and weakness JO - Personalized Medicine Journal JA - PMJ LA - en SN - 2476-5538 AU - Ghasemzadeh, Abbas AU - Esfahani, Vahidreza AD - ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR,Tehran, Iran AD - Department of Cellular and Molecular Tehran Medical Sciences Branch,lslamic Azad University, Tehran, Iran Y1 - 2021 PY - 2021 VL - 6 IS - 21 SP - 17 EP - 22 KW - Covid19 KW - ACE gene KW - TMPRSS2 gene KW - Infection DO - 10.22034/pmj.2021.244730 N2 - Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2), is a severe infection with respiratory and systemicmanifestations. This infectious disease has a complex course and manifests itself withvarious clinical presentations, ranging from asymptomatic infection to a severe clinicalcourse. These variations in severity have raised the question of whether the genetic orepigenetic variations have a role in COVID-19 susceptibility or severity, and that thesefactors can be used to predict the disease course. A whole-genome sequencing performedon 95 samples of SARS-CoV-2 identified 116 unique mutations, most of which weremissense and synonymous. Moreover, some studies have reported a relationship betweenthe COVID-19 severity and the genes ACE and TMPRSS2. The present review providesan overview of different genes that have been found to be implicated or related to thesusceptibility to COVID-19 or its severity. UR - https://www.pmjournal.ir/article_244730.html L1 - https://www.pmjournal.ir/article_244730_31b7d1361df9f341d51df05f9845d346.pdf ER -