TY - JOUR ID - 249631 TI - Polycystic ovary syndrome and genetic factors influencing its development: A review article JO - Personalized Medicine Journal JA - PMJ LA - en SN - 2476-5538 AU - Piri-Gharaghie, Tohid AD - Biotechnology Research Center, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Y1 - 2021 PY - 2021 VL - 6 IS - 23 SP - 25 EP - 29 KW - Polycystic Ovary Syndrome KW - PCOS KW - Genetics KW - Environmental DO - 10.22034/pmj.2021.249631 N2 - Polycystic ovary syndrome (PCOS) is a common infertility disorder, affecting a significant proportion of the global population. This syndrome has been one of the most controversial entities in gynecological endocrinology for many years. Both genes and the environment contribute to PCOS. Obesity, exacerbated by poor dietary choices, and physical inactivity, worsens PCOS in susceptible individuals. PCOS is a complex and heterogeneous disorder characterized by hyperandrogenemia, hyperinsulinemia, insulin resistance, and chronic anovulation. Many candidate genes have been identified to be one of the causes of PCOS. Different studies have been carried out to find the genetic correlation of PCOS. It is essential to carry out such studies that identify the clear cause of PCOS and its genetic association and hormonal disbalance. Currently, PCOS is considered a polygenic trait that might result from the interaction of susceptible and protective genomic variants and environmental factors, during either prenatal or postnatal life. UR - https://www.pmjournal.ir/article_249631.html L1 - https://www.pmjournal.ir/article_249631_a69d72c779cc5370a03891ddd6b01157.pdf ER -