TY - JOUR ID - 39036 TI - Investigation of the Relationship between PDYN Gene Polymorphisms and Tendency to Heroin Use JO - Personalized Medicine Journal JA - PMJ LA - en SN - 2476-5538 AU - Esfahani, Vahid Reza AU - Saremi, Mohammad Ali AD - Personalized Medicine Research Center of AmitisGen, Tehran, Iran Y1 - 2019 PY - 2019 VL - 4 IS - 15 SP - 4 EP - 6 KW - Heroin Addicts KW - gene polymorphism KW - Prodynorphins KW - RFLP KW - VNTR DO - 10.21859/pmj01032 N2 - Numerous studies have been conducted to investigate the relationship between genetic factors and drug use tendency, many of which have shown a significant correlation between genetic factors and drug use, especially heroin and cocaine. The most important site of drug action is the brain, which contains a variety of nerve receptors. Dynorphins are opioid peptides derived from the prodynorphins precursor (PDYN). These opioid peptides are capable of binding to the three types of opioid receptors. Studies have shown that heroin and cocaine use is associated with increased PDYN gene expression in specific areas of the brain. In this study, we investigated the association between rs910080 polymorphism in the 3'UTR region and the number of VNTR sequences in the promoter region with the tendency of heroin use in 155heroin addicts and 150 control with RFLP method. Results showed a significant relationship between heroin abuse and CC genotype in rs910080 polymorphism (P = 0.001), but no significant relationship between VNTR promoter repeats and heroin abuse. Rs910080 polymorphism can be used as a distinguishing factor. UR - https://www.pmjournal.ir/article_39036.html L1 - https://www.pmjournal.ir/article_39036_c325eff6648915308edcbe34e59b3fea.pdf ER -