TY - JOUR ID - 46382 TI - Effect of ascorbic acid treatment with angiogenesis JO - Personalized Medicine Journal JA - PMJ LA - en SN - 2476-5538 AU - Bakhshandeh Bavarsad, Sareh AU - Mohammadi, Amir AU - Shojaei, Najme AD - Department of public management, Faculty of management, University of Shahrekord, Iran AD - Department of Immunology, Asthma and Allergy Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran AD - Personalized Medicine Research Center of AmitisGen, Tehran, Iran Y1 - 2020 PY - 2020 VL - 5 IS - 18 SP - 17 EP - 19 KW - Vitamin C KW - Angiogenesis KW - carcinostatic KW - Breast cancer DO - 10.22034/pmj.2020.46382 N2 - Vitamin C plays is a cofactor for enzymes involved in many processes and has effects that are important for cancer transformation, such as antioxidant defense, transcription, and epigenetic regulation of gene expression.Angiogenesis is a normal process required for normal tissue repair and growth. Pathological angiogenesis is characterized by the persistent proliferation of endothelial cells and formation of blood vessels.The current study evaluated the effect of ascorbic acid on angiogenesis by investigating the expression of genes related to angiogenesis after treatment with different doses of ascorbic acid. By changing the concentration and administration time of ascorbic acid, a positive effect on the growth and metastasis of cancer cells in the group injected with ascorbic acid prior to having cancer cells injected into the abdominal cavity .  UR - https://www.pmjournal.ir/article_46382.html L1 - https://www.pmjournal.ir/article_46382_f2cfcf652c98cb80ea03aa228dc8db45.pdf ER -