TY - JOUR ID - 46383 TI - Introduction of two candidate microRNAs, –miR-21 and miR-146a, as biomarkers in MS JO - Personalized Medicine Journal JA - PMJ LA - en SN - 2476-5538 AU - Rahvar, Farzaneh AU - M. Mohammed, Fawziah AU - Seresht-Ahmadi, Mehrshad AU - Poorhasan, Nafise AD - Department of Medical genetic, national Institute for genetic Engineering and Biotechnology, Tehran, Iran AD - Faculty of Allied Health Sciences KuwaitnMedical Laboratory Sciences AD - Department of biology, Nourdanesh institute of higher education, Meymeh, Isfahan, Iran AD - Personalized Medicine Research Center of AmitisGen, Tehran, Iran Y1 - 2020 PY - 2020 VL - 5 IS - 18 SP - 20 EP - 23 KW - multiple sclerosis KW - miRNAs KW - Gene expression KW - CSF DO - 10.22034/pmj.2020.46383 N2 - The roles of miRNAs in autoimmunity are only beginning to be explored; they may be involved in regulating immune responses against self-tissues.miRNAs may contribute to disease progression and response to treatment in MS patients. Several studies on MS have analyzed the role or profile of miRNAs in different tissues including peripheral blood mononuclear cells (PBMCs).The current study evaluated mir-21 and mir-146a in CSF samples of patients with multiple sclerosis. Differential expression of the two miRNAs was detected in at least 80% of the CSF samples;however, additional functional studies and analyses of larger cohorts are needed to validate these results and to elucidate the real role of these miRNAs in the context of MS.  UR - https://www.pmjournal.ir/article_46383.html L1 - https://www.pmjournal.ir/article_46383_43d3014d9bc66a38e99e59664a92c822.pdf ER -