AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 5 19 2020 12 01 Evaluation of CENPM gene expression in cervical cancer 13 15 240046 10.22034/pmj.2020.240046 EN Raziye Amuzgar Kermanshah University of Medical Sciences, School of the Medicine, Kermanshah, Iran Najme Shojaei Personalized Medicine Research Center of AmitisGen, Tehran, Iran Journal Article 2020 12 21 Cervical cancer is the most widely screened cancer in the world both in high- and middle-income countries. HPV has been implicated in 99.7% of cervical squamous cell cancer cases worldwide. Viral E6 and E7 genes expression leads to alterations of the cellular genome integrity, including structural and numerical chromosomal instability resulting in chromosomal mis-segregation and aneuploidy. Centromere protein M (CENPM) is an essential centromere component for chromosome separation. In this study, we evaluated the expression of this gene at mRNA level by qRT-PCR method on 20 cancer samples who previously had feather papillomavirus infection, The results show a significant increase in the expression of this gene in cancer samples. cervical cancer Human papilloma virus Chromosomal Instability Gene expression https://www.pmjournal.ir/article_240046_932a7778bd9cb7e09268be1574c23365.pdf