AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 6 22 2021 09 20 The Role of Mitochondria in The Development and Progression of Cancer 27 33 246994 10.22034/pmj.2021.246994 EN Fateme Davodabadi Department of Biology, Faculty of Basic Science, Payame Noor University, Tehran, Iran Massoud Houshmand National Institute of Genetic Engineering and Biotechnology Journal Article 2021 07 11 Mitochondria are the extra-nuclear source of DNA in cells and play an important role in cell death susceptibility,  oxidative stress regulation, metabolism, and signaling in normal cells. Because of this, its dysfunction can contribute to the progression of cancer and metastasis. Also, mtDNA mutations have been reported in many cancers, followed by altered mitochondrial activity and cellular signaling . This increase in mtDNA mutation is due to the proximity of the genome to the OXPHOS system which are thought to be more in extent than mutation nuclear. These mutations do not inactivate energy metabolism but change its state. Therefore, it is not surprising that the function of mitochondria is vital for cancer cells, in addition to understanding the mechanisms of mitochondrial function in the process of tumor formation and cancer progression is essential for cancer treatments. https://www.pmjournal.ir/article_246994_8bab06c805d594465bc86eca9748af39.pdf