AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 7 24 2022 03 20 Investigating the Link Between MS and the EBV Virus 23 27 252441 10.22034/pmj.2022.252441 EN Bahareh Abbasi National Institute of Genetic Engineering and Biotechnology. Almas Araghi Department of Microbiology, Faculty of Biological Sciences, North Tehran Islamic Azad University, Tehran, Iran. AmirHossein Akbari Aghababa Department of Microbiology, Faculty of Biological Science, North Branch, Islamic Azad University, Tehran, Iran Journal Article 2021 11 23 Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Epstein–Barr virus (EBV) is a human DNA herpesvirus infecting more than 90% of the world's population. EBV is the etiological agent of infectious mononucleosis (Pfeiffer's disease). Major predisposing factors for MS are certain tissue types (e.g., HLA DRB1*15:01), vitamin D deficiency, smoking, obesity, and infection with Epstein-Barr virus (EBV). This review summarizes current knowledge on the association between EBV and MS. https://www.pmjournal.ir/article_252441_e2b45e2cd283fbc2d0f636cc74e13144.pdf