AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 7 24 2022 03 20 miR-22-3p as a Novel Biomarker in Rheumatoid Arthritis 19 22 252479 10.22034/pmj.2022.252479 EN Maryam Hassanpoor Department of cell and molecular biology,Faculty of biological sciences, Kharazmi university, Tehran, Iran Bahareh Abbasi National Institute of Genetic Engineering and Biotechnology. Journal Article 2022 01 14 Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune. Early diagnosis of RA remains challenging. A significant portion of RA patients also experience unremitting symptoms despite treatment. miRNA are involved in the regulation of autoimmunity- and inflammation-related processes. In this study, we evaluated the expression of miR-22-3p in serum of RA patients as a novel biomarker. Expression level of this gene in the blood serum of 30 people with RA compared with 30 healthy individuals by the qRT-PCR method. Results showed levels of miR22-3p were significantly higher in the serum of patients with RA in comparison with healthy control (p<0.0001). We suggest that miR 22-3p can be used as a biomarker in early detection and screening. Rheumatoid arthritis (RA) Micro RNA miR 22-3p Gene expression Autoimmune Disease https://www.pmjournal.ir/article_252479_0243a8ef81f9743e12d2aa430771e19d.pdf