AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 7 25 2022 06 20 TGF-β Isoforms and Receptors: A Gene Expression Analysis in Multiple Sclerosis Patients and Normal Individuals 43 47 253554 10.22034/pmj.2022.253554 EN Zeinab Shirvani-Farsani Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, IR Iran. Mehrdad Behmanesh Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran Mohammad Ali Sahraian MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Journal Article 2022 01 03 Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), depicted by lymphocytic infiltration and demyelination. MS is associated with the up-regulation of pro-inflammatory and down-regulation of anti-inflammatory cytokines. The purpose of this experimental study was to evaluate the expression level of TGF-β1, TGF-β 2, TGF-β-R1, and TGF-β-R2 mRNAs in peripheral blood mononuclear cells (PBMCs) from MS patients and healthy controls using Real-Time PCR. Our findings indicated that the TGF-β-R1 expression level was 2.25 times higher in controls than in MS patients. Also, a significant correlation between normalized expression of TGF-β-R1 and TGF-β1, or TGF-β2 was observed. Therefore, these genes could likely play an important role in the etiology of MS. https://www.pmjournal.ir/article_253554_dff333121fcd5c0d04ac8f118ef70824.pdf