AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 5 16 2020 03 01 rs78726532 TLR3 gene polymorphism with susceptibility to Hepatitis C virus infection 1 2 40424 10.22034/pmj.2020.40424 EN Blnd Ibrahim Mohammed Biology Department, College of Science, Salahaddin University-Erbil, Erbil, Iraq Saeed Megdadi Department of biology, Nourdanesh institute of higher education, Meymeh, Isfahan, Iran Vahid Reza Esfahani Personalized Medicine Research Center of AmitisGen, Tehran, Iran Journal Article 2019 12 26 HCV is a blood pathogen that affects approximately 180 million people worldwide. It has the ability to escape its host’s defense mechanism and is considered a resistant species. Toll-like receptors (TLRs) are a family of evolutionary receptors that have been identified by the diagnosis of pathogens as the main regulators of innate and acquired immune responses. Studies have shown that genetic changes in the TLR3 gene are associated with high susceptibility or resistance to immune and infectious diseases. In this study, the effects of the TLR3 gene single nucleotide polymorphism rs78726532 on susceptibility to HCV infections were examined. The association between this polymorphism and the risk of hepatitis C in 50 patients and 50 healthy subjects was investigated. The results revealed a significant relationship between polymorphism rs78726532 and hepatitis C infection (p = 0.002). Thus, it could have a therapeutic and predictive potential. https://www.pmjournal.ir/article_40424_c94230bd397e1a81b4f3e410ff14daf4.pdf