AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 5 18 2020 09 01 Effect of chemotherapy on sperm DNA fragmentation 1 3 46377 10.22034/pmj.2020.46377 EN Sadegh Sadegh Shojaei Baghini Plant Biotechnology, Agriculture Biotechnology Department, National Institute of Genetics Engineering and Biotechnology, Tehran, Iran. Ramadhan Ibrahim Fish Recourses and Aquatic Animals Department, College of Agriculture Salahaddin University, Erbil, Iraq Hosein Ahmadi Department of Medical genetic, national Institute for genetic Engineering and Biotechnology, Tehran, Iran Mona Nadi Personalized Medicine Research Center of AmitisGen, Tehran, Iran Journal Article 2020 10 21 Chemotherapy and radiotherapy adversely affect spermatogenesis, a consequence that is particularly relevant to young men who have yet to establish families. The harmful effects of chemotherapy on spermatogenesis are variable, depending on the type and dosage of chemotherapeutic agents used. The current study assessed the effect of cancer therapy on sperm DNA fragmentation by Comet assay. Sperm DNA fragmentation was evaluated in cured cancer patients. The results showed a significant relationship between chemotherapy and double-stranded and single-stranded sperm DNA fragmentation.<br /> <br />  https://www.pmjournal.ir/article_46377_c262b62c257bb4e97a9618c9bf4bacf5.pdf