AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 7 27 2022 12 20 Your Body on a Chip: Functional Testing for Personalized Medicine 1 7 700885 10.22034/pmj.2022.700885 EN Mona Aghassizadeh-Sherbaf Department of Microbiology, Faculty of Basic Sciences, East-Tehran Branch, Islamic Azad University, Tehran, Iran. Jumi Bora Department of Zoology, The Assam Royal Global University, Guwahati, Assam, India. Aynaz Mazandarani Department of Biochemistry, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran Journal Article 2022 08 07 Despite the well-known high prevalence of failure in drug development, recent advancements in tissue engineering and microfabrication have helped to create microphysiological systems (MPS), or "organs-on-chips," which mimic the function of human organs. These "tissue chips" might be used for toxicity and drug screening tests, which could revolutionize the early phases of the drug development process. Additionally, they may be utilized to simulate disease conditions, supplying new instruments for deciphering disease pathologies and causes and evaluating the efficacy of novel treatments. Future clinical trials on chips might be utilized to assess novel medicines in both populations and individuals, opening the door for precision medicine. Here, we'll discuss tissue chips' diverse potential and the difficulties in developing them. https://www.pmjournal.ir/article_700885_f72948ec5cb1ebd5aab3f161b4db742f.pdf