AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 8 30 2023 09 28 Evaluation of the low-Frequency Eelectromagnetic Fields on Biochemical Parameters in the Absence and Presence of Vitamin C in Mice 17 24 707856 10.22034/pmj.2023.2011493.1014 EN Melika Parsianmehr Department of Biology, Faculty of Science, Mashhad Branch, Islamic Azad University, Mashhad, Iran. Ali Neamati Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran 0000-0003-3571-1972 Masoud Homayouni Tabrizi Department of Biology, Faculty of Science, Mashhad Branch, Islamic Azad University, Mashhad, Iran. Sahar Abareshi Department of Biology, Faculty of Science, Mashhad Branch, Islamic Azad University, Mashhad, Iran. 0000-0003-3571-1972 Parisa Sanati Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, 71345-1978,Shiraz, Iran. 0000-0003-1483-3743 Journal Article 2023 05 13 Exposure to low-frequency electromagnetic fields (LF-EMF) has been considered a global concern because of its harmful effects on human health (cancer, neurodegenerative disorders, etc.). According to the International Agency for Research on Cancer, EMF has been classified as a possible cancerous element for human health. Antioxidants such as vitamin C improve the damage caused by EMF by reducing oxidative stress. To evaluate the effects of EMF on the serum total protein, blood sugar, albumin and triglyceride, and the inhibitory role of vitamin C, 40 male BALB/c mice were recruited. Participants were randomly distributed into four groups 1- exposure to LF-EMF, 2- exposure to LF-EMF which received vitamin C (50 mg/kg), 3- exposure to LF-EMF which received vitamin C (100 mg/kg), and 4- control group (no exposure). The experimental groups (1-3) received LF-EMF (50 Hz, 4 mT, 4 hours/day, and 1 month) while both groups 2 and 3 had intraperitoneally injected vitamin C (50 mg/kg, 100 mg/kg) every other day basis respectively. The obtained results demonstrated higher triglyceride and total protein levels and lower albumin and blood sugar levels in the LF-EMF group compared to controls while vitamin C restricts their alterations (p<0.05). To sum it up, our data show that intraperitoneal injection of vitamin C restricts the effects of LF-EMF exposure on the biochemical parameters in mice. However, the antioxidant characteristics of vitamin C may be probably involved in the LF-EMF effects of biochemical parameters in mice. https://www.pmjournal.ir/article_707856_7915bcb07b86e4e014007a5b8e04810b.pdf