AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 9 33 2024 06 22 Cancer Immunotherapy Using Microfluidic Systems 1 6 713763 10.22034/pmj.2024.713763 EN Maryam Diansaei Department of veterinary medicine, Islamic Azad University of Tabriz, Tabriz,Iran. 0009-0003-2329-2835 Parisa Sanati Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, 1978-71345, Shiraz, Iran 0000-0003-1483-3743 Journal Article 2024 02 12 Physicians are enthusiastic about using a novel approach known as cancer immunotherapy to address various forms of cancer. However, there are occasions when novel therapies that demonstrate efficacy in laboratory settings may not provide the same level of effectiveness when applied to actual patients. To address this issue, scientists are using miniature replicas known as microfluidic models. These models provide the examination of the interaction between cancer and immune cells in a manner that closely resembles the physiological conditions inside the human body. This review examines the role of microfluidic models in advancing the development of more effective cancer therapies. Let's begin by discussing the current state of affairs in cancer immunotherapy. Next, we explore the use of microfluidic models by scientists to gain insights into the mechanisms via which the immune system combats cancer and to evaluate the efficacy of novel therapeutic interventions. Additionally, we discuss the first measures used to demonstrate the efficacy of these models in predicting the effectiveness of therapies in human subjects. Lastly, we will discuss the advantages of using microfluidic models and the necessary steps to enhance their efficacy in the development of novel cancer therapies.<br><strong> </strong> https://www.pmjournal.ir/article_713763_a0979cd8d93cf0f321e6d38fcb7da81f.pdf