AmitisGen TECH Dev Group Personalized and Precision Medicine Journal 3115-7874 9 34 2024 09 30 Aptamer-Based Approaches in Oncology 9 13 715089 10.22034/pmj.2024.715089 EN Behnoush Khashei Department of pathobiology, faculty of veterinary science, Bu Ali Sina university, Hamedan, Iran 0000-0001-8401-9785 Parisa Haghpour Department of Biotechnology, Alzahra Universit, Tehran, Iran 0009-0000-2490-0060 Journal Article 2024 04 20 Cancer is a significant global cause of mortality, and enhancing therapy is essential to save lives and minimise adverse consequences. Aptamers, composed of DNA or RNA, have the potential for cancer treatment by precise targeting of certain molecules. Aptamers, unlike conventional therapies such as chemotherapy, have the specific objective of delivering medications directly to cancer cells, while reducing injury to healthy cells. This paper examines the process of aptamer development and utilisation in cancer treatment, with a specific emphasis on their capacity to enhance therapy and surmount drug resistance. Additionally, it explores the obstacles and potential advancements in using aptamers to transform cancer therapy. https://www.pmjournal.ir/article_715089_ddae3c96f1f0de87081aaf5a308fbd2a.pdf