Diabetes mellitus (DM) is a major public health issue in worldwide. Type 2 diabetes does not have a clear pattern of inheritance, although many affected individuals have at least one close family member, such as a parent or sibling, with the disease. The KCNJ11 gene is a member of the potassium channel gene family. polymorphisms in KCNJ11 result in neonatal diabetes and congenital hyper-insulinaemia, wherein the E23K (rs5219) polymorphism is linked with diabetes susceptibility where the K allele plays an important role in insulin secretion. In this study, we evaluate the frequency of these polymorphisms in a Kurdish population of 85 with type 2 diabetes. E23K polymorphism of KCNJ11 gene was genotyped by PCR-RFLP method. heterozygous carriers for AG are more in non‑diabetic patients (P = 0.034).
Houshmand, M., Najeeb, M. (2020). Association of the KCNJ11 rs5219 E23K polymorphism with Type 2 Diabetes. Personalized Medicine Journal, 5(19), 19-21. doi: 10.22034/pmj.2020.240048
MLA
Massoud Houshmand; Mohammed Najeeb. "Association of the KCNJ11 rs5219 E23K polymorphism with Type 2 Diabetes". Personalized Medicine Journal, 5, 19, 2020, 19-21. doi: 10.22034/pmj.2020.240048
HARVARD
Houshmand, M., Najeeb, M. (2020). 'Association of the KCNJ11 rs5219 E23K polymorphism with Type 2 Diabetes', Personalized Medicine Journal, 5(19), pp. 19-21. doi: 10.22034/pmj.2020.240048
VANCOUVER
Houshmand, M., Najeeb, M. Association of the KCNJ11 rs5219 E23K polymorphism with Type 2 Diabetes. Personalized Medicine Journal, 2020; 5(19): 19-21. doi: 10.22034/pmj.2020.240048
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