Association of the KCNJ11 rs5219 E23K polymorphism with Type 2 Diabetes

Document Type : Original Article

Authors

1 National Institute of Genetic Engineering and Biotechnology

2 NIGEB • Department of Medical Biotechnology

3 DeptofDiabetes& Internal Medicine, JarallahGerman Specialized Clinics, Kuwait

10.22034/pmj.2020.240048

Abstract

Diabetes mellitus (DM) is a major public health issue in worldwide. Type 2 diabetes does not have a clear pattern of inheritance, although many affected individuals have at least one close family member, such as a parent or sibling, with the disease. The KCNJ11 gene is a member of the potassium channel gene family. polymorphisms  in KCNJ11  result  in  neonatal  diabetes and congenital hyper-insulinaemia, wherein the E23K (rs5219) polymorphism is linked with diabetes susceptibility where the K allele plays an important role in insulin secretion. In this study, we evaluate the frequency of these polymorphisms in a Kurdish population of 85 with type 2 diabetes. E23K polymorphism of KCNJ11 gene was genotyped by PCR-RFLP method. heterozygous carriers for AG are more in non‑diabetic patients (P = 0.034).

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