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Volume 5 (2020)
Volume 4 (2019)

Personalized Medicine Journal is an open access Publication, accepting articles in Persian since 2016 until 2019. Afterwards, to share our knowledge worldwide, PMJ has started publishing English articles. PMJ welcomes original, review, novel and high-impact articles related to the personalized medicine issues. PMJ has been indexed in databases; Google scholar, Magiran, and CIVILICA. 

All submitted manuscripts are checked for similarity through a trustworthy software named iThenticate to be assured about its originality and then rigorously peer-reviewed by the reviewers. The review process of the manuscript normally takes 4-8 weeks. In addition, PMJ awards a prize to the most innovative article of the quarterly.

Review Article
The Role of DNA Methylation in Development and Progression of Rheumatoid Arthritis
The Role of DNA Methylation in Development and Progression of Rheumatoid Arthritis

Fawziah Mohammed; Seyed Akbar Moosavi

Volume 6, Issue 24 , 2022, Pages 1-7

http://dx.doi.org/10.22034/pmj.2022.252438

Abstract
  Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology that results in progressive joint destruction and ultimately to disability. Currently effective biologic ...  Read More
Review Article
Epithelial-Mesenchymal Rransition and its Role in Breast Cancer Metastasis
Epithelial-Mesenchymal Rransition and its Role in Breast Cancer Metastasis

Avan Saeed Mohammed; Ghazal Ghajari

Volume 6, Issue 24 , 2022, Pages 8-13

http://dx.doi.org/10.22034/pmj.2022.252439

Abstract
  Breast cancer is the most common cancer in women and distant site metastasis is the main cause of death in breast cancer patients. Epithelial-mesenchymal transition (EMT) is defined ...  Read More
Review Article
Androgens in Prostate Cancer: A Review Article
Androgens in Prostate Cancer: A Review Article

Nazar Shabila; Ghasem Ghorbani Vale Zaghard

Volume 6, Issue 24 , 2022, Pages 14-18

http://dx.doi.org/10.22034/pmj.2022.252440

Abstract
  Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. The androgen-signaling axis plays a pivotal ...  Read More
Original Article
miR-22-3p as a Novel Biomarker in Rheumatoid Arthritis
miR-22-3p as a Novel Biomarker in Rheumatoid Arthritis

Maryam Hassanpoor; Bahareh Abbasi

Volume 6, Issue 24 , 2022, Pages 19-22

http://dx.doi.org/10.22034/pmj.2022.252479

Abstract
  Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune. Early diagnosis of RA remains challenging. A significant portion of RA patients also experience unremitting symptoms ...  Read More
Review Article
Investigating the Link Between MS and the EBV Virus
Investigating the Link Between MS and the EBV Virus

Bahareh Abbasi; Almas Araghi; AmirHossein Akbari Aghababa

Volume 6, Issue 24 , 2022, Pages 23-27

http://dx.doi.org/10.22034/pmj.2022.252441

Abstract
  Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Epstein–Barr virus (EBV) is a human DNA herpesvirus ...  Read More
Review Article
A Review of the Role of Exosomes in Prostate Cancer
A Review of the Role of Exosomes in Prostate Cancer

Rafid A Abdulkareem; Seyed Majid Hashemi Fard; Masoomeh Kohandani

Volume 6, Issue 24 , 2022, Pages 28-32

http://dx.doi.org/10.22034/pmj.2022.252442

Abstract
  Prostate cancer (PCa) is the most common solid tumor in men. While patients with local PCa have better prognostic survival, patients with metastatic PCa have relatively high mortality ...  Read More
Comparison of different methods of DNA extraction from paraffin-embedded tissues
Comparison of different methods of DNA extraction from paraffin-embedded tissues

Ramadhan Ibrahim; Saeed Megdadi; Sareh Bakhshandeh bavarsad; Najme Shojaei

Volume 5, Issue 17 , June 2020, , Pages 5-8

http://dx.doi.org/10.22034/pmj.2020.43452

Abstract
  The most common human archival specimens are formalin-fixed and paraffin-embedded tissues. PCR-based techniques have been coupled with new developments in the extraction of DNA from ...  Read More
Increased expression of the lnc H19 gene in the plasma of people with breast cancer
Increased expression of the lnc H19 gene in the plasma of people with breast cancer

kazhaleh Mohammadi; Sadegh Shojaei Baghini; Mohammad Ali Saremi

Volume 5, Issue 17 , June 2020, , Pages 12-14

http://dx.doi.org/10.22034/pmj.2020.43454

Abstract
  The majority of ncRNAs are known as long non-coding RNAs (lncRNAs) whose length exceeds 200 nucleotides. H19, a lncRNA, is the transcription product of the H19 gene, an oncogene in ...  Read More
Analysis of EGFR gene mutations in tissue samples of lung cancer tumors
Analysis of EGFR gene mutations in tissue samples of lung cancer tumors

Blnd Ibrahim Mohammed; Amir Mohammadi; Nafise Poorhasan

Volume 5, Issue 17 , June 2020, , Pages 1-4

http://dx.doi.org/10.22034/pmj.2020.43451

Abstract
  Lung cancer is the leading cause of cancer deaths worldwide. Approximately 25% of nonsmall-cell lung cancers have mutations in the EGFR gene, most of which occur in hotspot regions ...  Read More
Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism and Pemetrexed Treatment Outcome in Patients with Non–Small-Cell Lung Cancer
Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism and Pemetrexed Treatment Outcome in Patients with Non–Small-Cell Lung Cancer

Mohammad Hadi Abbasian; Nafiseh Ansarinejad; Tayeb Ramim; Farshid Fardad; Bahareh Abbasi

Volume 6, Issue 23 , December 2021, , Pages 5-9

http://dx.doi.org/10.22034/pmj.2021.249035

Abstract
  Background: Lung cancer is the first cause of cancer deaths in the world. Pemetrexed is an antifolate drug used as a first or second-line in the treatment of advanced non-small cell ...  Read More
Effect of ascorbic acid treatment with angiogenesis
Effect of ascorbic acid treatment with angiogenesis

Sareh Bakhshandeh Bavarsad; Amir Mohammadi; Najme Shojaei

Volume 5, Issue 18 , September 2020, , Pages 17-19

http://dx.doi.org/10.22034/pmj.2020.46382

Abstract
  Vitamin C plays is a cofactor for enzymes involved in many processes and has effects that are important for cancer transformation, such as antioxidant defense, transcription, and epigenetic ...  Read More
Original Article
rs78726532 TLR3 gene polymorphism with susceptibility to Hepatitis C virus infection
rs78726532 TLR3 gene polymorphism with susceptibility to Hepatitis C virus infection

Blnd Ibrahim Mohammed; Saeed Megdadi; Vahid Reza Esfahani

Articles in Press, Accepted Manuscript, Available Online from 10 June 2020

http://dx.doi.org/10.22034/pmj.2020.40358

Abstract
  HCV is a blood pathogen that affects approximately 180 million people worldwide. It has the ability to escape its host’s defense mechanism and is considered a resistant species. ...  Read More
Original Article
Effects of iron oxide nanoparticles on MDA-MB-231 breast breast cell line
Effects of iron oxide nanoparticles on MDA-MB-231 breast breast cell line

Ramadhan Ibrahim; Mohammad Ali Saremi; Mohammad Ali Keshavarz Shahbaz; Maryam forouhi

Articles in Press, Corrected Proof, Available Online from 10 June 2020

http://dx.doi.org/10.22034/pmj.2020.40359

Abstract
  Because of their small size, unique physics, and chemical properties, metal nanoparticles can easily cross obstacles and reach their target cells, which makes them an ideal choice for ...  Read More
Original Article
Investigating the relationship between polymorphism rs406193 and the risk of prostate cancer
Investigating the relationship between polymorphism rs406193 and the risk of prostate cancer

Fawziah M. Mohammed; Amir Mohammadi; Najme Shojaei

Articles in Press, Corrected Proof, Available Online from 10 June 2020

http://dx.doi.org/10.22034/pmj.2020.40360

Abstract
  In many cancers, an increase in gene expression of DNMT3b has been reported. This enzyme inhibits the expression of many tumor suppressor genes through the methylation of the promoter ...  Read More
Evaluation of the relationship between intronic polymorphism TPO gene and risk of type 2 diabetes in Tehran population
Evaluation of the relationship between intronic polymorphism TPO gene and risk of type 2 diabetes in Tehran population

Massoud Houshmand; Mehrshad Seresht-Ahmadi; Mahsa Alikarami

Articles in Press, Corrected Proof, Available Online from 10 June 2020

http://dx.doi.org/10.22034/pmj.2020.40361

Abstract
  Obesity and type 2 diabetes are two complex disorders with strong genetic backgrounds, and both disorders cause other diseases and increase mortality. FTO is a protein-coding gene located ...  Read More
Original Article
Investigation of p16 gene promoter methylation in people with cervical cancer and women with papilloma virus infection
Investigation of p16 gene promoter methylation in people with cervical cancer and women with papilloma virus infection

Abdulkarim Karim; Hadi Yari; Ehsan Razeghian; Ali Reza Miri Lavasani

Articles in Press, Corrected Proof, Available Online from 10 June 2020

http://dx.doi.org/10.22034/pmj.2020.40362

Abstract
  Cervical cancer is the second most common cancer and an important cause of death in women worldwide. Objective biomarkers are needed to improve specificity for cervical cancer screening. ...  Read More
Evaluation of miRNA-21 expression in plasma samples of breast cancer patients
Evaluation of miRNA-21 expression in plasma samples of breast cancer patients

kazhaleh Mohammadi; Mehrdad Tavakoli; Nafise Poorhasan; Maryam forouhi

Articles in Press, Corrected Proof, Available Online from 10 June 2020

http://dx.doi.org/10.22034/pmj.2020.40363

Abstract
  According to the World Health Organization, one in eight to ten women will develop breast cancer. Therefore, the development of new blood / serum markers is important as an alternative ...  Read More
Original Article
The effect of vitamin D treatment on the sperm parameters of mice treated with busulfan
The effect of vitamin D treatment on the sperm parameters of mice treated with busulfan

Sahar Hassannejad; Reza Ghamari; Mohammad Ali Saremi; Sadegh Shojaei Baghini

Articles in Press, Corrected Proof, Available Online from 10 June 2020

http://dx.doi.org/10.22034/pmj.2020.40364

Abstract
  Spermatogenesis is a very complex process that can be affected by a number of factors which may lead to reduced fertility or infertility. Busulfan kills spermatogonia stem cells and ...  Read More
Personalized Medicine Journal

Publisher:
AmitisGen Med Tech Group

Editor-in-Chief:
Prof. Massoud Houshmand

Senior Editor:
Dr. Roya Amirinejad

Managing Editor:
Dr. Mohammad Ali Saremi

Executive Manager:
Nayyere Moslehi

Frequency: Quarterly

Online ISSN: 2717-3860

Indexing and Abstracting

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CIVILICA

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