Personalized and Precision Medicine Journal

Abstract Microbiome means microbes coexisting with the host, regardless of the species, in a part of the body of an organism called microbiome. Nowadays, changes in gut microbiota are considered as a potential therapeutic approach for the prevention or treatment of colorectal cancer (CRC).Studies have shown that dietary habits and lifestyle play a role in modulating the gut microbiota.
Intestinal microbiota plays a role in converting food components into oncometabolites. Some studies showed that Shigella, Citrobacter and Salmonella bacteria are more abundant in the early stages of cancer compared to healthy people. The aim of this study is to review the role of microbiomes in the development of colorectal cancer and the metabolites produced by microbiomes in the development of colorectal cancer.

Abstract Preimplantation genetic diagnosis is recognized as an effective approach to rule out embryos with abnormal chromosomes in hopes of increasing the chances of a successful pregnancy. The objective of this study is to evaluate the association between types of single cell (blastomere) chromosomal aneuploidy and female partner age using Next Generation Sequencing technique. This study showed that 70.80% of tested samples had abnormal chromosomal complementation, regardless of maternal age or complexity of the abnormality present. 

Abstract Polycystic ovary syndrome (PCOS) is a common infertility disorder, affecting a significant proportion of the global population. This syndrome has been one of the most controversial entities in gynecological endocrinology for many years. Both genes and the environment contribute to PCOS. Obesity, exacerbated by poor dietary choices, and physical inactivity, worsens PCOS in susceptible individuals. PCOS is a complex and heterogeneous disorder characterized by hyperandrogenemia, hyperinsulinemia, insulin resistance, and chronic anovulation. Many candidate genes have been identified to be one of the causes of PCOS. Different studies have been carried out to find the genetic correlation of PCOS. It is essential to carry out such studies that identify the clear cause of PCOS and its genetic association and hormonal disbalance. Currently, PCOS is considered a polygenic trait that might result from the interaction of susceptible and protective genomic variants and environmental factors, during either prenatal or postnatal life.