Document Type : Original Article


1 Department of microbiology, karaj branch, Islamic Azad University, karaj, Iran

2 Maya Milk, Inc, Delaware, USA



Genetic studies, there is a potential association of RELN with some psychological
disorders such as Autism Spectrum Disorders (ASD) schizophrenia (SCZ). The RELN
gene is located on chromosome 7q22.1 and encodes a large secretory protein of the
extracellular matrix (Reelin). In the present case-control study, we intended to investigate
the relationship between the rs362746 polymorphism of RELN and schizophrenia in a
group of schizophrenic and healthy subjects from northeastern Iran.30 unrelated schizophrenic patients and 30 matched control subjects were recruited The samples
from the participants underwent PCR and sequencing for RELN genotype identification.he genotype distribution for  both study and control groups were not in Hardy–Weinberg equilibrium(P>0.05).However, it was found that the prevalence of
rs362746 polymorphism was significantly different between the groups. the present study supported the evidence that rs362746 polymorphism of RELN was a
genetic factor for schizophrenia susceptibility. However, there is a need for replication
studies on different populations and further investigations on the sex-specific association
of this gene with schizophrenia.