Personalized and Precision Medicine Journal
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Investigating the causes of antibiotic resistance in bacteria

Document Type : Review Article

Authors

AmirHossein Akbari Aghababa 1
Mona Nadi 2

1 Department of Micrbiology, Faculty of biology, Islamic Azad University, North Branch,Tehran, Iran

2 Department of Cell and Molecular Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran

https://doi.org/10.22034/pmj.2021.244729
Abstract
The discovery and production of (synthetic) antibiotics in the first half of the previous century has been one of medicine’s greatest achievements. The use of antimicrobial agents has reduced morbidity and mortality of humans and contributed substantially to human’s increased life span. The issue of antibiotic resistance has received considerable attention due to the problem of the emergence and rapid expansion of antibiotic-resistant pathogenic bacteria. Antibiotic resistance exhibited by bacteria can be intrinsic, acquired, or adaptive. Therefore, efforts to develop antibiotics and study mechanisms of resistance should be continuous, resilient and steady. In the following sections, we will focus on the molecular and biochemical mechanisms of bacterial resistance, illustrating specific situations that are often encountered in clinical practice.

Keywords

Antibiotic resistance
Bacteria
Horizontal Gene Transfer
Efflux Pumps
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Personalized and Precision Medicine Journal
Volume 6, Issue 21
Original article
Spring 2021
Pages 7-11

  • Receive Date 06 April 2021
  • Revise Date 26 April 2021
  • Accept Date 01 May 2021

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