Document Type : Original Article

Authors

1 Department of Pediatrics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

2 General Practitioner (GP), Tabriz University of Medical Sciences, Tabriz, Iran

3 General Practitioner (GP), Shahid Beheshti University of Medical Sciences, Tehran, Iran

10.21859/pmj04014

Abstract

Introduction: Recent scientific promotion reveals that medicine is currently at a transition stage from programmatic to personalized handling on in infectious diseases. Methods: Herrien, this research was performed to evaluation seropositivity for L. monocytogenes based on personalized medicine among the women with and without annals of miscarriage by indirect immunofluorescence test (IIFA). Moreover, the relationship of seropositivity with demographic factors was also investigated. Results: Our outcome showed that 26.92% (35 cases) of women with an involuntary miscarriage were seropositive for L. monocytogenes, while 11% (11 cases) of healthy pregnant women were found positive for L. monocytogenes (P = 0.001). The most case of listeria has been found in age group of 30-35 years old, but no notable difference was found among different groups (P = 0.245). Moreover, there was a considerable association between listeria occurrence and history of abortion when compared with healthy pregnant women (P = 0.001). In addition, early abortion and the number of pregnancy were significantly linked to Listeria- seropositive in patients with spontaneous abortion (P = 0.041; P = 0.034). Conclusions: Further researches are required to appraise the clinical importance of L. monocytogenesin in pregnant women with symptomatic and asymptomatic infection related to personalized medicine.

Keywords

1.Jensen SO, van Hal SJ. Personalized Medicine and Infectious
Disease Management. Trends Microbiol. 2017;25(11):875-6.
doi: 10.1016/j.tim.2017.09.006 pmid: 28969882
2. Al-Mozaini MA, Mansour MK. Personalized medicine. Is it
time for infectious diseases? Saudi Med J. 2016;37(12):1309-
11. doi: 10.15537/smj.2016.12.16837 pmid: 27874145
3. Lecuit M. Understanding how Listeria monocytogenes targets
and crosses host barriers. Clin Microbiol Infect.
2005;11(6):430-6. doi: 10.1111/j.1469-0691.2005.01146.x
pmid: 15882192
4. Neuhaus K, Satorhelyi P, Schauer K, Scherer S, Fuchs TM.
Acid shock of Listeria monocytogenes at low environmental
temperatures induces prfA, epithelial cell invasion, and
lethality towards Caenorhabditis elegans. BMC Genomics.
2013;14:285. doi: 10.1186/1471-2164-14-285 pmid:
23622257
5. Painter J, Slutsker L. Listeriosis in Humans. Boca Raton,
Florida: Taylor and Francis Group; 2007. 85-109 p.
6. Mylonakis E, Paliou M, Hohmann EL, Calderwood SB, Wing
EJ. Listeriosis During Pregnancy. Medicine. 2002;81(4):260-
9. doi: 10.1097/00005792-200207000-00002
7. Kaur S, Malik SV, Vaidya VM, Barbuddhe SB. Listeria
monocytogenes in spontaneous abortions in humans and its
detection by multiplex PCR. J Appl Microbiol.
2007;103(5):1889-96. doi: 10.1111/j.1365-
2672.2007.03414.x pmid: 17953598
8. Carminati D, Perrone A, Giraffa G, Neviani E, Mucchetti G.
Characterization of Listeria monocytogenes strains isolated
from Gorgonzola cheese rinds. Food Microbiol.
2004;21(6):801-7. doi: 10.1016/j.fm.2004.01.011
9. Donato R, Sacco C, Tiscione E, Galassi L, Scarpellini A,
Ademollo B. Comparison between plate count agar and milk
plate count agar in evaluation of total bacterial charge in
pasteurized milk [Italy]. Latter (Italy). 1994:19-24.
10. Klatt EC, Pavlova Z, Teberg AJ, Yonekura ML. Epidemic
perinatal listeriosis at autopsy. Hum Pathol.
1986;17(12):1278-81. pmid: 3793087
11. Silver HM. Listeriosis during pregnancy. Obstet Gynecol Surv.
1998;53(12):737-40. pmid: 9870235
12. Jackson TL, Eykyn SJ, Graham EM, Stanford MR. Endogenous
bacterial endophthalmitis: A 17-year prospective series and
review of 267 reported cases. Surv Ophthalmol.
2003;48(4):403-23. doi: 10.1016/s0039-6257(03)00054-7
13. Kida K, Osada N, Isahaya K, Mikami T, Yoneyama K, Kongoji
K, et al. Listeria endocarditis with acute thoracoabdominal
aortic dissection. Intern Med. 2007;46(15):1209-12. pmid:
17675771.Cardoso C, Cremers I, Oliveira AP. Spontaneous bacterial
peritonitis caused by Listeria monocytogenes: a case report
and literature review. Ann Hepatol. 2012;11(6):955-7. pmid:
23109462
15. Vargas V, Aleman C, de Torres I, Castells L, Gavalda J,
Margarit C, et al. Listeria monocytogenes-associated acute
hepatitis in a liver transplant recipient. Liver. 1998;18(3):213-
5. pmid: 9716234
16. Stepanovic S, Vukovic D, Djukic S, Cirkovic I, Svabic-Vlahovic
M. Long-term analysis of Listeria monocytogenes vaginal
carriage frequency in Belgrade, Serbia (short communication).
Acta Microbiol Immunol Hung. 2007;54(2):195-9. doi:
10.1556/AMicr.54.2007.2.9 pmid: 17899798
17. Haghroosta A, Shakh AF, Shooshtari MM. Investigation on the
seroprevalence of Listeria monocytogenes in women with
spontaneous abortion. Comp Clin Pathol. 2014;24(1):153-6.
doi: 10.1007/s00580-013-1876-4
18. McLauchlin J. Listeriosis. BMJ. 1992;304(6842):1583-4.
pmid: 1628083
19. Jamshidi M, Jahromi AS, Davoodian P, Amirian M, Zangeneh
M, Jadcareh F. Seropositivity for Listeria monocytogenes in
women with spontaneous abortion: a case-control study in
Iran. Taiwan J Obstet Gynecol. 2009;48(1):46-8. doi:
10.1016/S1028-4559(09)60034-6 pmid: 19346191
20. Lida L. Prevalence and antimicrobial resistance profiles of
Listeria monocytogenes in spontaneous abortions in humans.
Afr J Microbiol Res. 2011;5(14). doi: 10.5897/ajmr11.498
21. Aljicevic M, Beslagic E, Zvizdic S, Hamzic S, Mahmutovic S.
[Agglutination as screening test in routine diagnostic of
listeriosis]. Med Arh. 2006;60(2):93-5. pmid: 16528925
22. Pujol I, Vidal A, Joven J. [The seroprevalence of Listeria
infections without clinical sign in a population of pregnant
women from the Reus area]. Rev Clin Esp. 1990;187(4):175-
7. pmid: 2128653
23. Tahery Y, Kafilzadeh F, Momtaz YA. Listeria monocytogenesis
and abortion: A case study of pregnant women in Iran. Afr J
Microbiol Res. 2009;3(11):826-32.
24. Mascola L, Ewert DP, Eller A. Listeriosis: A previously
unreported medical complication in women with multiple
gestations. Am J Obstet Gynecol. 1994;170(5):1328-32. doi:
10.1016/s0002-9378(94)70151-2