Document Type : Original Article
Author
Personalized Medicine Research Center of AmitisGen, Tehran, Iran
Abstract
The use of silver as an antibacterial goes back to ancient times. Adding a small number of silver nanoparticles to different surfaces can cause the antimicrobial coating. Use at high doses has toxic effects, which can alter cell morphology, increase oxidative stress, increase membrane permeability, decrease cell growth, and ultimately cause cell death through apoptosis or necrosis. In this study, we evaluated the antioxidant effect of kombucha beverage in mice treated with silver nanoparticles. The amount of SOD, CAT, MAD, and GST enzymes were evaluated in four groups include control groups, silver nanoparticles treated, Cambodian beverage treatment, and Nano + kombucha treated. The results showed an increase in oxidative stress after treatment with silver nanoparticles. It has also demonstrated that kombucha drinks can have a protective role and reduce the oxidative stress induced by silver nanoparticles. It is therefore suggested that it can be used as a potent antioxidant against silver nanoparticles.
Keywords
toxic effects after oral exposure and underlying mechanisms--a
review. Food Chem Toxicol. 2015;77:58-63. doi:
10.1016/j.fct.2014.12.019 pmid: 25556118
2. Priya SD, Sharmila S, Nusrath T. Synthesis of plant mediated
silver nanoparticles and antimicrobial activity in Cucumis
sativa. J Natur Prod Plant Resour. 2013;3(2):23-30.
3. Abbasi E, Milani M, Fekri Aval S, Kouhi M, Akbarzadeh A,
Tayefi Nasrabadi H, et al. Silver nanoparticles: Synthesis
methods, bio-applications and properties. Crit Rev Microbiol.
2016;42(2):173-180. doi: 10.3109/1040841X.2014.912200
pmid: 24937409
4. Kokura S, Handa O, Takagi T, Ishikawa T, Naito Y, Yoshikawa
T. Silver nanoparticles as a safe preservative for use in
cosmetics. Nanomedicine. 2010;6(4):570-574. doi:
10.1016/j.nano.2009.12.002 pmid: 20060498
5. Shrivastava S, Bera T, Roy A, Singh G, Ramachandrarao P,
Dash D. Characterization of enhanced antibacterial effects of
novel silver nanoparticles. Nanotechnology. 2007;18(22). doi:
10.1088/0957-4484/18/22/225103
6. Kim S, Choi JE, Choi J, Chung KH, Park K, Yi J, et al. Oxidative
stress-dependent toxicity of silver nanoparticles in human
hepatoma cells. Toxicol In Vitro. 2009;23(6):1076-1084. doi:
10.1016/j.tiv.2009.06.001 pmid: 19508889
7. Suliman YA, Ali D, Alarifi S, Harrath AH, Mansour L, Alwasel
SH. Evaluation of cytotoxic, oxidative stress, proinflammatory
and genotoxic effect of silver nanoparticles in human lung
epithelial cells. Environ Toxicol. 2015;30(2):149-160. doi:
10.1002/tox.21880 pmid: 23804405
8. Sievers M, Lanini C, Weber A, Schuler-Schmid U, Teuber M.
Microbiology and Fermentation Balance in a Kombucha
Beverage Obtained from a Tea Fungus Fermentation. Systemd
Applied Microbiol. 1995;18(4):590-594. doi: 10.1016/s0723-
2020(11)80420-0
9. Steinkraus KH, Shapiro KB, Hotchkiss JH, Mortlock RP.
Investigations into the antibiotic activity of tea
fungus/kombucha beverage. Acta Biotechnologica. 1996;16(2-
3):199-205. doi: 10.1002/abio.370160219
10. Bauer-Petrovska B, Petrushevska-Tozi L. Mineral and water
soluble vitamin content in the Kombucha drink. Int J Food Sci
Technol. 2000;35(2):201-205. doi: 10.1046/j.1365-
2621.2000.00342.x
11. Nandhini NT. Kombucha Fungus Mediated Silver
Nanoparticles and their Biological Activities. Int J Applied
Bioeng. 2017;11(2):190-199.
12. Shariatzadeh SMA, Nemati A. The effects of nigella sativa oil
on kidney nephron structure NMRI mice treated with high
dose of silver nanoparticles. J Dev Biol. 2017;9(2):41-55.
13. Setroki Doodi A, Hooshmand M. The effect of Cambodian tea
on oxidative stress parameters in hypercholesterolemic rabbits.
Neyshabour J Med Sci. 2018;6(2):49-58.
14. Gharib OA. Effects of Kombucha on oxidative stress induced
nephrotoxicity in rats. Chin Med. 2009;4:23. doi:
10.1186/1749-8546-4-23 pmid: 19943946
)