Personalized and Precision Medicine Journal
Where Innovations Meets Personalized and Precision Medicine

Frequency of Human Papillomavirus Types in Women with Genital Warts by Probe-based Real-time PCR

Document Type : Original Article

Author

Mohammad Javanbakht

Urology and Nephrology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

10.21859/pmj01036
Abstract
The second most common cancer and the fourth leading cause of death in women is cervical cancer. In 90% of cases of human papillomavirus infections, HPV is the cause of this cancer. More than 200 different types of the virus have been identified, including low-risk and high-risk variants. According to statistics, infections from types 16 and 18 of the virus account for 70% of cervical cancers. This cancer is preventable, and one of the ways to prevent it is to have regular screenings. Probe-based real-time PCR methods are more accurate and sensitive methods for detection. In this study, we performed HPV typing with probed base real-time PCR in 50 genital wart samples and checking the relationship between questionnaire information.

Keywords

Cervical Cancer HPV Real
time PCR Screening
1. Hajibagheri K, Abaszade A, Afrasiabian S, Verdi F, Roshani D,
Abdi F, et al. Frequency of human papilloma virus genotypes
Among woman with genitalia lesion, Sanandaj, Iran. Sci J
Kurdistan Uni Med Sci. 2018;23(4):46-52.
2. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer
statistics, 2007. CA Cancer J Clin. 2007;57(1):43-66. doi:
10.3322/canjclin.57.1.43 pmid: 17237035
3. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC,
Wacholder S. Human papillomavirus and cervical cancer.
Lancet. 2007;370(9590):890-907. doi: 10.1016/S0140-
6736(07)61416-0 pmid: 17826171
4. Gissmann L, Diehl V, Schultz-Coulon HJ, zur Hausen H.
Molecular cloning and characterization of human papilloma
virus DNA derived from a laryngeal papilloma. J Virol.
1982;44(1):393-400. pmid: 6292500
5. Klug A, Finch JT. Structure of Viruses of the Papilloma-
Polyoma Type. I. Human Wart Virus. J Mol Biol. 1965;11:403-
423. doi: 10.1016/s0022-2836(65)80066-3 pmid: 14290353
6. Clifford G, Franceschi S, Diaz M, Munoz N, Villa LL. Chapter
3: HPV type-distribution in women with and without cervical
neoplastic diseases. Vaccine. 2006;24 Suppl 3:S3/26-34. doi:
10.1016/j.vaccine.2006.05.026 pmid: 16950015
7. McCormack PL, Joura EA. Quadrivalent human
papillomavirus (types 6, 11, 16, 18) recombinant vaccine
(Gardasil(R)): a review of its use in the prevention of
premalignant genital lesions, genital cancer and genital warts in
women. Drugs. 2010;70(18):2449-2474. doi:
10.2165/11204920-000000000-00000 pmid: 21142263
8. Brink AA, Snijders PJ, Meijer CJ. HPV detection methods. Dis
Markers. 2007;23(4):273-281. doi: 10.1155/2007/147429
pmid: 17627062
9. Lo Muzio L, D'Angelo M, Procaccini M, Bambini F, Calvino F,
Florena AM, et al. Expression of cell cycle markers and human
papillomavirus infection in oral squamous cell carcinoma: use
of fuzzy neural networks. Int J Cancer. 2005;115(5):717-723.
doi: 10.1002/ijc.20940 pmid: 15729691
10. Romero-Morelos P, Uribe-Jimenez A, Bandala C, Poot-Velez
A, Ornelas-Corral N, Rodriguez-Esquivel M, et al. Genotyping
of the human papilloma virus in a group of Mexican women
treated in a highly specialist hospital: Multiple infections and
their potential transcendence in the current vaccination
programme. Med Clin (Barc). 2017;149(7):287-292. doi:
10.1016/j.medcli.2017.02.021 pmid: 28438378
Personalized and Precision Medicine Journal
Volume 4, Issue 15 - Serial Number 3
Original article
Autumn 2019
Pages 16-18

  • Receive Date 18 April 2020

Home

Publication Ethics

Guide for Authors

Submit Manuscript

Contact Us