Personalized and Precision Medicine Journal
Where Innovations Meets Personalized and Precision Medicine

Evaluation of miRNA-21 expression in plasma samples of breast cancer patients

Document Type : Original Article

Authors

kazhaleh Mohammadi 1
Mehrdad Tavakoli 2
Nafise Poorhasan 3
Maryam forouhi 4

1 Researcher and lecture assistant at the Medical Laboratory Science Department, Knowledge University, Kurdistan Region, Erbil, Iraq

2 Department of biology, Zanjan, Islamic azad university, Zanjan, Iran

3 Personalized Medicine Research Center of AmitisGen, Tehran, Iran

4 National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

https://doi.org/10.22034/pmj.2020.40429
Abstract
According to the World Health Organization, one in eight to ten women will develop breast cancer. Therefore, the development of new blood / serum markers is important as an alternative to traditional diagnosis methods. Early detection of breast cancer plays an important role in choosing the right treatment approach and treating the patient. In this study, the expression of miRNA21 gene in the plasma sample of people with breast cancer compared to healthy people was evaluated. The results of qPCR showed that the expression levels of miRNA-21 in the plasma samples of breast cancer patients were significantly increased compared to those of the healthy controls. These results suggest that Mir 21 could be a very good blood biomarker for the early detection of breast cancer.

Keywords

breast cancer
blood biomarker
MicroRNA-21
gene expression
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Personalized and Precision Medicine Journal
Volume 5, Issue 16
Original article
Winter 2020
Pages 15-16

  • Receive Date 21 January 2020
  • Accept Date 01 March 2020

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